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193902-78-2

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  • SAGECHEM/tert-Butyl 4-(5-nitropyridin-2-yl)piperazine-1-carboxylate/SAGECHEM/Manufacturer in China

    Cas No: 193902-78-2

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193902-78-2 Usage

General Description

1-BOC-4-(5-NITRO-2-PYRIDYL)PIPERAZINE is a chemical compound that belongs to the class of chemicals known as piperazines. Piperazines are compounds containing a piperazine ring, a six-membered ring with two nitrogen atoms and four carbon atoms. The presence of the 5-nitro-2-pyridyl group indicates that the compound has nitro functional group (-NO2) attached to a pyridine ring, a six-membered ring with two nitrogen atoms and four carbon atoms. The BOC in the name denotes that the compound is further modified with a tert-butoxycarbonyl group, which is commonly used in organic chemistry to protect amines. The properties and uses of 1-BOC-4-(5-NITRO-2-PYRIDYL)PIPERAZINE are primarily determined by the reactivity of these functional groups.

Check Digit Verification of cas no

The CAS Registry Mumber 193902-78-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,3,9,0 and 2 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 193902-78:
(8*1)+(7*9)+(6*3)+(5*9)+(4*0)+(3*2)+(2*7)+(1*8)=162
162 % 10 = 2
So 193902-78-2 is a valid CAS Registry Number.
InChI:InChI=1/C14H20N4O4/c1-14(2,3)22-13(19)17-8-6-16(7-9-17)12-5-4-11(10-15-12)18(20)21/h4-5,10H,6-9H2,1-3H3

193902-78-2 Well-known Company Product Price

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  • Aldrich

  • (654191)  1-Boc-4-(5-nitro-2-pyridyl)piperazine  97%

  • 193902-78-2

  • 654191-1G

  • 356.85CNY

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  • Aldrich

  • (654191)  1-Boc-4-(5-nitro-2-pyridyl)piperazine  97%

  • 193902-78-2

  • 654191-10G

  • 1,882.53CNY

  • Detail

193902-78-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl 4-(5-nitropyridin-2-yl)piperazine-1-carboxylate

1.2 Other means of identification

Product number -
Other names 1-tert-Butoxycarbonyl-4-(5-nitropyrid-2-yl)piperazine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:193902-78-2 SDS

193902-78-2Relevant articles and documents

Synthesis, Antibacterial and Anthelmintic Activity of Novel 3-(3-Pyridyl)-oxazolidinone-5-methyl Ester Derivatives

Chen, Jia-Yi,Jin, Bo,Sheng, Zun-Lai,Sun, Meng-Qing,Yang, Hong-Liang

, (2022/02/14)

In this study, a series of 3-(3-pyridyl)-oxazolidone-5-methyl ester derivatives was synthesized and characterized by1H NMR,13C NMR, and LC-MS. The conducted screening antibacterial studies of the new 3-(3-pyridyl)-oxazolidone-5-methyl ester derivatives established that the methyl sulfonic acid esters have broad activity spectrum towards Staphylococcus aureus, Streptococcus pneu-moniae, Bacillus subtilis and Staphylococcus epidermidis. Among them, compound 12e has the most potent activity, with an MIC of 16 μg/mL against B.subtilis, and could reduce the instantaneous growth rate of bacteria. Furthermore, molecular docking studies were also simulated for compound 12e to predict the specific binding mode of this compound. In addition, anthelmintic activity of these compounds was also evaluated against adult Indian earthworms (Pheretima posthuman). The results showed that compound 11b had the best effect. These results above can provide experimental ref-erence for the development of novel antibacterial and anthelmintic drugs.

COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY

-

Page/Page column 241, (2021/07/10)

This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said che

Seeking potent anti-tubercular agents: Design and synthesis of substituted-: N -(6-(4-(pyrazine-2-carbonyl)piperazine/homopiperazine-1-yl)pyridin-3-yl)benzamide derivatives as anti-tubercular agents

Aggarwal, Himanshu,Calster, Kevin Van,Cappoen, Davie,Chandra Sekhar, Kondapalli Venkata Gowri,De Voogt, Linda,Ghosh, Balaram,Murugesan, Sankaranarayanan,Nandikolla, Adinarayana,Srinivasarao, Singireddi,Suresh, Amaroju

, p. 12272 - 12288 (2020/04/20)

Pyrazinamide is an important first-line drug used in shortening TB therapy. In our current work, a series of novel substituted-N-(6-(4-(pyrazine-2-carbonyl)piperazine/homopiperazine-1-yl)pyridin-3-yl)benzamide derivatives were designed, synthesized, and evaluated for their anti-tubercular activity against Mycobacterium tuberculosis H37Ra. Among the tested compounds, five compounds (6a, 6e, 6h, 6j and 6k) from Series-I and one compound (7e) from Series-II exhibited significant activity against Mycobacterium tuberculosis H37Ra with 50% inhibitory concentrations (IC50) ranging from 1.35 to 2.18 μM. To evaluate the efficacy of these compounds, we examined their IC90 values. Five of the most active compounds were found to be more active with IC90s ranging from 3.73 to 4.00 μM and one compound (6e) showed an IC90 of 40.32 μM. Moreover, single crystals were developed for 6d, 6f and 6n. In addition, most active compounds were evaluated for their cytotoxicity on HEK-293 (human embryonic kidney) cells. Our results indicate that the compounds are nontoxic to human cells. The molecular interactions of the derivatised conjugates in docking studies reveal their suitability for further development.

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