4-Cyano-2-fluorobenzeneboronic acid, pinacol ester

Base Information

• Chemical Name: 4-Cyano-2-fluorobenzeneboronic acid, pinacol ester
• CAS No.: 1035235-29-0
• Molecular Formula: C13H15BFNO2
• Molecular Weight: 247.077
• Hs Code.: 2934999090
• Mol file: 1035235-29-0.mol

Synonyms:4-Cyano-2-fluorophenylboronic acid, pinacol ester

Chemical Property of 4-Cyano-2-fluorobenzeneboronic acid, pinacol ester

Chemical Property:

• PSA: 42.25000
• LogP: 1.99658

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Cyano-2-fluorobenzeneboronic acid, pinacol ester

There total 1 articles about 4-Cyano-2-fluorobenzeneboronic acid, pinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-bromo-3-fluorobenzonitrile (133059-44-6) + bis(pinacol)diborane (73183-34-3) → 3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile (1035235-29-0)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 110 ℃; Inert atmosphere;

Reference yield: 90.0%

3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile (1035235-29-0) + C22H12Cl2F2N2 → C36H18F4N4

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; In water; toluene; at 110 ℃; for 20h; Inert atmosphere;

Reference yield: 80.0%

4-chloro-3-fluoro-pyridine (2546-56-7) + 3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile (1035235-29-0) → C12H6F2N2

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate; In ethanol; water; toluene; at 80 ℃; for 10h; Inert atmosphere;

upstream raw materials:

4-bromo-3-fluorobenzonitrile

bis(pinacol)diborane

Downstream raw materials:

N-((5-(4-cyano-2-fluorophenyl)pyridin-3-yl)(cyclopropyl)methyl)ethanesulfonamide

3-fluoro-4-[4-(1-hydroxy-ethyl)-pyridin-3-yl]-benzonitrile

C₂₅H₂₃FN₄O₄S

C₂₀H₁₇FN₄O₂S*ClH