7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinolin-1(2H)-one

Base Information

• Chemical Name: 7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinolin-1(2H)-one
• CAS No.: 1231892-74-2
• Molecular Formula: C15H20BNO3
• Molecular Weight: 273.14
• Hs Code.: 2934999090
• Mol file: 1231892-74-2.mol

Synonyms:7-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,4-dihydro-2H-isoquinolin-1-one;7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinolin-1(2H)-one;

Chemical Property of 7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinolin-1(2H)-one

Chemical Property:

• PSA: 51.05000
• LogP: 1.28210
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinolin-1(2H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinolin-1(2H)-one

There total 12 articles about 7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinolin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

7-chloro-1,2,3,4-tetrahydroisoquinolin-1-one (22245-95-0) + bis(pinacol)diborane (73183-34-3) → 7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinolin-1(2H)-one (1231892-74-2)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium acetate; XPhos; In 1,4-dioxane; at 80 ℃; for 17.5h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.8b00421

Reference yield: 73.0%

1-oxo-1,2,3,4-tetrahydroisoquinolin-7-yl trifluoromethanesulfonate + bis(pinacol)diborane (73183-34-3) → 7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinolin-1(2H)-one (1231892-74-2)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 80 ℃; Inert atmosphere;

Reference yield: 72.0%

7-bromo-3,4-dihydroisoquinolin-1(2 H)-one (891782-60-8) + bis(pinacol)diborane (73183-34-3) → 7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinolin-1(2H)-one (1231892-74-2)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; at 70 ℃; Inert atmosphere;

upstream raw materials:

7-bromo-3,4-dihydroisoquinolin-1(2 H)-one

bis(pinacol)diborane

methyl 4-(bromophen)ethylcarbamate

2-4-methoxyphenylethylcarbamic acid methyl ester

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