2,3-Dihydroxymethylpyridine hydrochloride

Base Information

• Chemical Name: 2,3-Dihydroxymethylpyridine hydrochloride
• CAS No.: 423169-40-8
• Molecular Formula: C7H9NO2.ClH
• Molecular Weight: 175.615
• Hs Code.: 2933399090
• European Community (EC) Number: 850-961-2
• DSSTox Substance ID: DTXSID00590577
• Mol file: 423169-40-8.mol

Synonyms:423169-40-8;2,3-Dihydroxymethylpyridine hydrochloride;pyridine-2,3-diyldimethanol hydrochloride;[3-(hydroxymethyl)pyridin-2-yl]methanol hydrochloride;C7H10ClNO2;2,3-Dihydroxymethylpyridine HCl;[2-(hydroxymethyl)pyridin-3-yl]methanol;hydrochloride;2,3-Bis(hydroxymethyl)pyridine hydrochloride;pyridine-2,3-diyldimethanol hcl;AMY3649;DTXSID00590577;XHNKWLMBRMJUTQ-UHFFFAOYSA-N;bis(oxymethyl)pyridine hydrochloride;MFCD08436996;AKOS015920294;SB54654;pyridine-2,3-diyldimethanolhydrochloride;s11918;AS-65068;CS-0060369;EN300-127160;A872905;(Pyridine-2,3-diyl)dimethanol--hydrogen chloride (1/1);F8880-3849;(2-hydroxymethyl-pyridin-3-yl)-methanol hydrogen chloride;[2-(HYDROXYMETHYL)PYRIDIN-3-YL]METHANOL HYDROCHLORIDE

Chemical Property of 2,3-Dihydroxymethylpyridine hydrochloride

Chemical Property:

• PSA: 53.35000
• LogP: 0.86820
• Storage Temp.: Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 175.0400063
• Heavy Atom Count: 11
• Complexity: 97.6

Purity/Quality:

97% ^*data from raw suppliers

Pyridine-2,3-diyldimethanolhydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(N=C1)CO)CO.Cl

Technology Process of 2,3-Dihydroxymethylpyridine hydrochloride

There total 2 articles about 2,3-Dihydroxymethylpyridine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

dimethyl 2,3-pyridinedicarboxylate (605-38-9) → 2,3-bis(hydroxymethyl)pyridine hydrochloride (423169-40-8)

Guidance literature:

With hydrogenchloride; sodium tetrahydroborate; In ethanol;

DOI:10.1021/op3002728

Reference yield:

Pyridine-2,3-dicarboxylic acid (89-00-9) → 2,3-bis(hydroxymethyl)pyridine hydrochloride (423169-40-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid

2: sodium tetrahydroborate; hydrogenchloride / ethanol

With hydrogenchloride; sodium tetrahydroborate; sulfuric acid; In ethanol;

DOI:10.1021/op3002728

Reference yield: 89.0%

2,3-bis(hydroxymethyl)pyridine hydrochloride (423169-40-8) → 2,3-bis(chloromethyl)-pyridine (45754-12-9)

Guidance literature:

With thionyl chloride; In toluene;

DOI:10.1021/op3002728

upstream raw materials:

dimethyl 2,3-pyridinedicarboxylate

Pyridine-2,3-dicarboxylic acid

Downstream raw materials:

2,3-bis(chloromethyl)pyridine hydrochloride

2,3-bis(chloromethyl)-pyridine

6,7-dihydro-5H-pyrrolo[3,4-b]pyridine

(4-difluoromethoxy-3-pyridin-2-ylethynyl-phenyl)-(5,7-dihydro-pyrrolo[3,4-b]pyridin-6-yl)-methanone