2,3-bis(chloroMethyl)pyridine hydrochloride

Base Information

• Chemical Name: 2,3-bis(chloroMethyl)pyridine hydrochloride
• CAS No.: 27221-49-4
• Molecular Formula: C7H8Cl3N
• Molecular Weight: 212.506
• Hs Code.: 2933399990
• Mol file: 27221-49-4.mol

Synonyms:2,3-bis(chloroMethyl)pyridine hydrochloride;2,3-Bis-chloroMethyl-pyridine.HCl

Chemical Property of 2,3-bis(chloroMethyl)pyridine hydrochloride

Chemical Property:

• PSA: 12.89000
• LogP: 3.36120

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,3-Bis(chloromethyl)pyridinehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,3-Bis(chloromethyl)pyridine hydrochloride is used as a reactant in the preparation of an mGluR5 neg. allosteric modulator.

Technology Process of 2,3-bis(chloroMethyl)pyridine hydrochloride

There total 5 articles about 2,3-bis(chloroMethyl)pyridine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,3-bis(hydroxymethyl)pyridine (38070-79-0) → 2,3-bis(chloromethyl)pyridine hydrochloride (27221-49-4)

Guidance literature:

With thionyl chloride;

Reference yield:

2,3-bis(hydroxymethyl)pyridine hydrochloride (423169-40-8) → 2,3-bis(chloromethyl)pyridine hydrochloride (27221-49-4)

Guidance literature:

With thionyl chloride; at 5 - 20 ℃; for 16h; Inert atmosphere;

Reference yield:

dimethyl 2,3-pyridinedicarboxylate (605-38-9) → 2,3-bis(chloromethyl)pyridine hydrochloride (27221-49-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ethanol; calcium chloride; sodium tetrahydroborate / 16 h / 5 - 20 °C / Inert atmosphere

1.2: 1 h / 20 °C

1.3: Cooling with ice

2.1: thionyl chloride / 16 h / 5 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; thionyl chloride; ethanol; calcium chloride;

upstream raw materials:

2,3-bis(hydroxymethyl)pyridine

dimethyl 2,3-pyridinedicarboxylate

2,3-bis(hydroxymethyl)pyridine hydrochloride

Pyridine-2,3-dicarboxylic acid

Downstream raw materials:

2,3-bis(chloromethyl)-pyridine

6-(2,4-dimethoxybenzyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine

Refernces

• 1、 Melnykov, Kostiantyn P.,Volochnyuk, Dmitriy M.,Ryabukhin, Sergey V.,Rusanov, Eduard B.,Grygorenko, Oleksandr O.. "A conformationally restricted GABA analogue based on octahydro-1H-cyclopenta[b]pyridine scaffold". . p. 255 - 261. Retrieved 2019.
• 2、 Reddy, G. Prashanth,Bandichhor, Rakeshwar. "A novel synthesis of (4aS,7aS)-Octahydro-1H-pyrrolo[3,4-b]pyridine:An intermediate of Moxifloxacin Hydrochloride". . p. 8701 - 8707. Retrieved 2013/11/06.