3-(2-Chloro-2-oxoacetyl)-1H-indol-4-yl acetate

Base Information

Chemical Name:3-(2-Chloro-2-oxoacetyl)-1H-indol-4-yl acetate
CAS No.:952006-34-7
Molecular Formula:C12H8ClNO4
Molecular Weight:265.653
Hs Code.:
Mol file:952006-34-7.mol

Synonyms:Reaxys ID: 9775794;3-(2-chloro-2-oxoacetyl)-1H-indol-4-yl acetate;1H-Indole-3-acetyl chloride, 4-(acetyloxy)-α-oxo-

Suppliers and Price of 3-(2-Chloro-2-oxoacetyl)-1H-indol-4-yl acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of 3-(2-Chloro-2-oxoacetyl)-1H-indol-4-yl acetate

Chemical Property:

Boiling Point:478.7±48.0 °C(Predicted)
PKA:13.67±0.30(Predicted)
PSA：76.23000
Density:1.479±0.06 g/cm3(Predicted)
LogP:2.04130

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 3-(2-Chloro-2-oxoacetyl)-1H-indol-4-yl acetate

There total 2 articles about 3-(2-Chloro-2-oxoacetyl)-1H-indol-4-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 79-37-8
oxalyl dichloride

: 5585-96-6
acetic acid 1H-indol-4-yl ester

: 952006-34-7
3-(2-chloro-2-oxoacetyl)-1H-indol-4-yl acetate

Guidance literature:: In tetrahydrofuran; at 0 - 20 ℃; for 12h;

Reference yield:

: 2380-94-1
1H-indol-4-ol

: 952006-34-7
3-(2-chloro-2-oxoacetyl)-1H-indol-4-yl acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 34 g / pyridine / CH₂Cl₂ / 2 h / 20 °C

2: diethyl ether; hexane / cooling

With pyridine; In diethyl ether; hexane; dichloromethane;

Reference yield: 99.0%

: 103-49-1
dibenzylamine

: 952006-34-7
3-(2-chloro-2-oxoacetyl)-1H-indol-4-yl acetate

: 77872-23-2
3-(2-(dibenzylamino)-2-oxoacetyl)-1H-indol-4-yl acetate

Guidance literature:: dibenzylamine; 3-(2-chloro-2-oxoacetyl)-1H-indol-4-yl acetate; In tetrahydrofuran; at 0 - 10 ℃; for 1h; Inert atmosphere; Sealed tube;

With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/acs.jnatprod.9b01061