2-Fluoro-3-iodopyrazine

Base Information

• Chemical Name: 2-Fluoro-3-iodopyrazine
• CAS No.: 206278-26-4
• Molecular Formula: C4H2FIN2
• Molecular Weight: 223.976
• DSSTox Substance ID: DTXSID00572070
• Nikkaji Number: J962.692A
• Wikidata: Q82460325
• Mol file: 206278-26-4.mol

Synonyms:2-fluoro-3-iodopyrazine;206278-26-4;2-fluoro-3-iodo-pyrazine;MFCD17677156;SCHEMBL1304104;DTXSID00572070;ZGDOFCZYQIJHRG-UHFFFAOYSA-N;AKOS015950457;SY272495;CS-0105763;D76573;EN300-4263237;W-206543

Chemical Property of 2-Fluoro-3-iodopyrazine

Chemical Property:

• PSA: 25.78000
• LogP: 1.22030
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 223.92467
• Heavy Atom Count: 8
• Complexity: 80.4

Purity/Quality:

98%min ^*data from raw suppliers

2-Fluoro-3-iodopyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=C(C(=N1)F)I

Technology Process of 2-Fluoro-3-iodopyrazine

There total 3 articles about 2-Fluoro-3-iodopyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

2-fluoropyrazine (4949-13-7) → 2-fluoro-3-iodopyrazine (206278-26-4) + 2-fluoro-3,6-diiodopyrazine + 2-fluoro-3,5,6-triiodopyrazine

Guidance literature:

2-fluoropyrazine; With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.0833333h;

With iodine; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

DOI:10.1016/S0040-4020(01)01140-1

Reference yield:

2-fluoropyrazine (4949-13-7) → 2-fluoro-3-iodopyrazine (206278-26-4)

Guidance literature:

With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; iodine; Yield given. Multistep reaction; 1.) hexane, THF, -50 deg C to 0 deg C, 20 min; -78 deg C, 5 min, 2.) THF, -78 deg C, 60 min;

DOI:10.1016/S0040-4020(98)00173-2

Reference yield:

→ 2-fluoro-3-iodopyrazine (206278-26-4)

Guidance literature:

upstream raw materials:

2-fluoropyrazine

Downstream raw materials:

2-fluoro-3-(4-n-octyloxyphenyl)pyrazine

2-fluoro-3-phenylpyrazine

3-(2,3-fluoro-4-(n-octyloxy)phenyl)-2-fluoropyrazine

3-(2,3-fluoro-4-(n-hexyloxy)phenyl)-2-fluoropyrazine