Ethyl 3-amino-6-phenyl-4-(trifluoromethyl)furo[2,3-b]pyridine-2-carboxylate

Base Information

Chemical Name:Ethyl 3-amino-6-phenyl-4-(trifluoromethyl)furo[2,3-b]pyridine-2-carboxylate
CAS No.:160436-48-6
Molecular Formula:C17H13F3N2O3
Molecular Weight:350.297
Hs Code.:2934999090
European Community (EC) Number:646-575-7
ChEMBL ID:CHEMBL3127598
Nikkaji Number:J681.746G
Mol file:160436-48-6.mol

Synonyms:160436-48-6;Ethyl 3-amino-4-(trifluoromethyl)-6-phenylfuro[2,3-b]pyridine-2-carboxylate;ethyl 3-amino-6-phenyl-4-(trifluoromethyl)furo[2,3-b]pyridine-2-carboxylate;Ethyl 3-amino-6-phenyl-4-(trifluoromethyl)furo(2,3-b)pyridine-2-carboxylate;CHEMBL3127598;MFCD03934051;AKOS024407987;J-009722;ethyl3-amino-6-phenyl-4-(trifluoromethyl)furo[2,3-b]pyridine-2-carboxylate

Suppliers and Price of Ethyl 3-amino-6-phenyl-4-(trifluoromethyl)furo[2,3-b]pyridine-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Ethyl3-amino-6-phenyl-4-(trifluoromethyl)furo[2,3-b]pyridine-2-carboxylate 95+%
1g
$ 308.00

Crysdot
Ethyl3-amino-6-phenyl-4-(trifluoromethyl)furo[2,3-b]pyridine-2-carboxylate 95+%
5g
$ 1386.00

American Custom Chemicals Corporation
ETHYL 3-AMINO-4-(TRIFLUOROMETHYL)-6-PHENYLFURO[2,3-B]PYRIDINE-2-CARBOXYLATE 95.00%
10G
$ 7882.88

American Custom Chemicals Corporation
ETHYL 3-AMINO-4-(TRIFLUOROMETHYL)-6-PHENYLFURO[2,3-B]PYRIDINE-2-CARBOXYLATE 95.00%
5G
$ 4244.63

American Custom Chemicals Corporation
ETHYL 3-AMINO-4-(TRIFLUOROMETHYL)-6-PHENYLFURO[2,3-B]PYRIDINE-2-CARBOXYLATE 95.00%
1G
$ 1030.84

AK Scientific
Ethyl3-amino-4-(trifluoromethyl)-6-phenylfuro[2,3-b]pyridine-2-carboxylate
1g
$ 469.00

AK Scientific
Ethyl3-amino-4-(trifluoromethyl)-6-phenylfuro[2,3-b]pyridine-2-carboxylate
250mg
$ 274.00

Total 2 raw suppliers

Chemical Property of Ethyl 3-amino-6-phenyl-4-(trifluoromethyl)furo[2,3-b]pyridine-2-carboxylate

Chemical Property:

Boiling Point:476.3±45.0 °C(Predicted)
PKA:0.16±0.40(Predicted)
PSA：78.35000
Density:1.373±0.06 g/cm3(Predicted)
LogP:4.85370
XLogP3:4.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:4
Exact Mass:350.08782677
Heavy Atom Count:25
Complexity:482

Purity/Quality:

99% ^*data from raw suppliers

Ethyl3-amino-6-phenyl-4-(trifluoromethyl)furo[2,3-b]pyridine-2-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(C2=C(O1)N=C(C=C2C(F)(F)F)C3=CC=CC=C3)N

Technology Process of Ethyl 3-amino-6-phenyl-4-(trifluoromethyl)furo[2,3-b]pyridine-2-carboxylate

There total 4 articles about Ethyl 3-amino-6-phenyl-4-(trifluoromethyl)furo[2,3-b]pyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.3%

: 155635-64-6
ethyl 2-((3-cyano-6-(phenyl)-4-(trifluoromethyl)pyridin-2-yl)oxy)acetate

: 160436-48-6
2-carbethoxy-3-amino-4-trifluoromethyl-6-phenylfuro-<2,3-b>-pyridine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 110 - 120 ℃; for 3h;
DOI:10.1016/0022-1139(94)03079-0

Reference yield:

: 3335-44-2
2-oxo-6-phenyl-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile

: 160436-48-6
2-carbethoxy-3-amino-4-trifluoromethyl-6-phenylfuro-<2,3-b>-pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 94.5 percent / K₂CO₃, NaI / acetone / 4 h / 60 °C

2: 82.3 percent / K₂CO₃ / dimethylformamide / 3 h / 110 - 120 °C

With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; acetone;
DOI:10.1016/0022-1139(94)03079-0

Reference yield:

: 326-06-7
1-Phenyl-4,4,4-trifluorobutane-1,3-dione

: 160436-48-6
2-carbethoxy-3-amino-4-trifluoromethyl-6-phenylfuro-<2,3-b>-pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 1,4-diaza-bicyclo[2.2.2]octane / ethanol / 20 °C / Reflux

2: caesium carbonate / N,N-dimethyl-formamide / 7 h / 20 - 60 °C / Inert atmosphere

With 1,4-diaza-bicyclo[2.2.2]octane; caesium carbonate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.01.075