Imidazo[1,2-a]pyridin-8-ylmethanol

Base Information

• Chemical Name: Imidazo[1,2-a]pyridin-8-ylmethanol
• CAS No.: 111477-17-9
• Molecular Formula: C8H8N2O
• Molecular Weight: 148.16200
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID30452452
• Wikidata: Q82273098
• Mol file: 111477-17-9.mol

Synonyms:Imidazo[1,2-a]pyridin-8-ylmethanol;111477-17-9;Imidazo[1,2-a]pyridine-8-methanol;Imidazo[1,2-a]pyridin-8-yl-methanol;8-Hydroxymethylimidazo[1,2-a]pyridine;SCHEMBL2315461;DTXSID30452452;GXRHUJOMCLYOGR-UHFFFAOYSA-N;MFCD13183234;AKOS016006225;PB25508;{imidazo[1,2-a]pyridin-8-yl}methanol;AS-50985;CS-0049338;EN300-190802;P11610;F2185-0500

Chemical Property of Imidazo[1,2-a]pyridin-8-ylmethanol

Chemical Property:

• PKA: 13.12±0.10(Predicted)
• PSA: 37.53000
• Density: 1.26±0.1 g/cm3(Predicted)
• LogP: 0.82660
• Storage Temp.: 2-8°C
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 148.063662883
• Heavy Atom Count: 11
• Complexity: 140

Purity/Quality:

97% ^*data from raw suppliers

Imidazo[1,2-a]pyridin-8-ylmethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN2C=CN=C2C(=C1)CO

Technology Process of Imidazo[1,2-a]pyridin-8-ylmethanol

There total 6 articles about Imidazo[1,2-a]pyridin-8-ylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

imidazo[1,2-a]pyridine-8-carboxylic acid ethyl ester (158020-74-7) → 8-hydroxymethylimidazo[1,2-a]pyridine (111477-17-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 3h;

DOI:10.1021/jo015582x

Reference yield: 40.0%

methyl 8-imidazo<1,2-a>pyridinecarboxylate (133427-07-3) → 8-hydroxymethylimidazo[1,2-a]pyridine (111477-17-9)

Guidance literature:

methyl 8-imidazo<1,2-a>pyridinecarboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at 20 ℃; for 6h; Inert atmosphere;

With sodium hydroxide; In tetrahydrofuran; diethyl ether; water; at 0 - 20 ℃; for 0.25h;

Reference yield:

2-chloroethanal (107-20-0) + (2-amino-3-pyridinyl)methanol (23612-57-9) → 8-hydroxymethylimidazo[1,2-a]pyridine (111477-17-9)

Guidance literature:

With sodium hydrogencarbonate; In ethanol;

upstream raw materials:

imidazo[1,2-a]pyridine-8-carboxylic acid ethyl ester

2-aminopyridine-3-carboxylic acid ethyl ester

2-chloroethanal

(2-amino-3-pyridinyl)methanol

Downstream raw materials:

2-(imidazo[1,2-a]pyridin-8-ylmethoxy)-5-methoxybenzaldehyde

8-(chloromethyl)-imidazol[1,2-a]pyridine

(Z)-ethyl α-[(triphenylphosphoranylideneamino)-β-(imidazo[1,2-a]pyridin-8-yl)]propenoate

8-imidazo<1,2-a>pyridinecarboxaldehyde