1-Piperidinecarboxylic acid, 3,4-dimethyl-4-[3-(1-methylethoxy)phenyl]-, phenyl ester, (3R-cis)-

Base Information

• Chemical Name: 1-Piperidinecarboxylic acid, 3,4-dimethyl-4-[3-(1-methylethoxy)phenyl]-, phenyl ester, (3R-cis)-
• CAS No.: 145678-86-0
• Molecular Formula: C23H29NO3
• Molecular Weight: 367.488
• Mol file: 145678-86-0.mol

Synonyms:PHENYL (3R,4R)-3,4-DIMETHYL-4-[3-(PROPAN-2-YLOXY)PHENYL]PIPERIDINE-1-CARBOXYLATE;

Chemical Property of 1-Piperidinecarboxylic acid, 3,4-dimethyl-4-[3-(1-methylethoxy)phenyl]-, phenyl ester, (3R-cis)-

Chemical Property:

• Boiling Point: 483.8±45.0 °C(Predicted)
• PSA: 38.77000
• Density: 1.078±0.06 g/cm3(Predicted)
• LogP: 5.21020

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Piperidinecarboxylic acid, 3,4-dimethyl-4-[3-(1-methylethoxy)phenyl]-, phenyl ester, (3R-cis)-

There total 11 articles about 1-Piperidinecarboxylic acid, 3,4-dimethyl-4-[3-(1-methylethoxy)phenyl]-, phenyl ester, (3R-cis)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

C17H27NO*C20H18O8 (1184775-81-2,145415-19-6) + phenyl chloroformate (1885-14-9) → (3R,4R)-3,4-dimethyl-4-<3-(1-methylethoxy)phenyl>piperidinecarboxylic acid phenyl ester (145678-86-0)

Guidance literature:

C₁₇H₂₇NO*C₂₀H₁₈O₈; With HO^-;

phenyl chloroformate; In toluene; for 2h; Reflux;

DOI:10.13005/ojc/340246

Reference yield: 97.0%

phenyl chloroformate (1885-14-9) + (3R,5R)-1,3,4-trimethyl-4-<3-(1-methylethoxy)phenyl>piperidine (143919-34-0,145340-46-1,1431704-21-0) → (3R,4R)-3,4-dimethyl-4-<3-(1-methylethoxy)phenyl>piperidinecarboxylic acid phenyl ester (145678-86-0)

Guidance literature:

In toluene; for 2h; Heating;

DOI:10.1021/jo951403y

Reference yield:

(3RS,4SR)-1,2,3,4-tetrahydro-1,3,4-trimethyl-4-<3-(1-methylethoxy)phenyl>pyridine → (3R,4R)-3,4-dimethyl-4-<3-(1-methylethoxy)phenyl>piperidinecarboxylic acid phenyl ester (145678-86-0)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄ / methanol / 3 h / 25 °C

2: 97 percent / toluene / 2 h / Heating

With sodium tetrahydroborate; In methanol; toluene;

DOI:10.1021/jo951403y

upstream raw materials:

phenyl chloroformate

(3R,5R)-1,3,4-trimethyl-4-<3-(1-methylethoxy)phenyl>piperidine

(R)-1,2,3,4-tetrahydro-1,3-dimethyl-4-<3-(1-methylethoxy)phenyl>pyridine

C₁₇H₂₇NO*C₂₀H₁₈O₈

Downstream raw materials:

ADL 08-0011

(+)-<<2'(S)-<<4(R)-3-(hydroxyphenyl)-3(R),4-dimethyl-1-piperidinyl>methyl>-1-oxo-3-phenylpropyl>amino>acetic acid 2-methylpropyl ester

Entereg

2‐((R)‐2‐benzyl‐3‐((3R,4R)‐4‐(3‐hydroxyphenyl)‐3,4‐dimethylpiperidin‐1‐yl)propanamido)acetic acid