Carbamic acid, (5-amino-2,4-difluorophenyl)-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, (5-amino-2,4-difluorophenyl)-, 1,1-dimethylethyl ester
CAS No.:179741-60-7
Molecular Formula:C11H14F2N2O2
Molecular Weight:244.241
Hs Code.:
Mol file:179741-60-7.mol

Synonyms:tert-butyl 5-amino-2,6-difluorophenylcarbamate;N-(t-butoxycarbonyl)-4,6-difluoro-m-phenylenediamine;N-(tert-butoxycarbonyl)-4,6-difluoro-m-phenylenediamine;tert-butyl 5-amino-2,4-difluorophenylcarbamate;tert-butyl 5-amino-2, 4-difluorophenylcarbamate;(5-Amino-2,4-difluoro-phenyl)-carbamic acid tert-butyl ester;

Suppliers and Price of Carbamic acid, (5-amino-2,4-difluorophenyl)-, 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of Carbamic acid, (5-amino-2,4-difluorophenyl)-, 1,1-dimethylethyl ester

Chemical Property:

Melting Point:120 - 121 °C
PSA：64.35000
LogP:3.54820

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Carbamic acid, (5-amino-2,4-difluorophenyl)-, 1,1-dimethylethyl ester

There total 6 articles about Carbamic acid, (5-amino-2,4-difluorophenyl)-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 179741-61-8
tert-butyl (2,4-difluoro-5-nitrophenyl)carbamate

: 179741-60-7
tert-butyl (5-amino-2,4-difluorophenyl)carbamate

Guidance literature:: With hydrogen; palladium; In methanol; at 20 ℃; for 72h;
DOI:10.1021/jm0205090

Reference yield:

: 153775-33-8
2,4-difluoro-5-nitro-benzoic acid

: 179741-60-7
tert-butyl (5-amino-2,4-difluorophenyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl chloride; DMF / CH₂Cl₂ / 18 h / 20 °C

2: sodium azide / CH₂Cl₂; dimethylformamide / 0.33 h / 20 °C

3: 149 g / CH₂Cl₂; dimethylformamide / 2 h / Heating

4: 75 percent / H₂ / palladium black / methanol / 72 h / 20 °C

With sodium azide; oxalyl dichloride; hydrogen; N,N-dimethyl-formamide; palladium; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0205090

Reference yield:

: 221560-09-4
2,4-Difluoro-5-nitrobenzoyl Chloride

: 179741-60-7
tert-butyl (5-amino-2,4-difluorophenyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide / CH₂Cl₂; dimethylformamide / 0.33 h / 20 °C

2: 149 g / CH₂Cl₂; dimethylformamide / 2 h / Heating

3: 75 percent / H₂ / palladium black / methanol / 72 h / 20 °C

With sodium azide; hydrogen; palladium; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0205090