2-(azetidin-3-yl)pyridine dihydrochloride

Base Information

• Chemical Name: 2-(azetidin-3-yl)pyridine dihydrochloride
• CAS No.: 206446-45-9
• Molecular Formula: C8H10N2.2ClH
• Molecular Weight: 207.10000
• Hs Code.: 2933990090
• Mol file: 206446-45-9.mol

Synonyms:azetidinylpyridinedihydrochloride;2-(azetidin-3-yl)pyridine dihydrochloride;

Chemical Property of 2-(azetidin-3-yl)pyridine dihydrochloride

Chemical Property:

• Melting Point: 174～175℃
• PSA: 24.92000
• LogP: 2.70120
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

2-(Azetidin-3-yl)pyridinedihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(azetidin-3-yl)pyridine dihydrochloride

There total 3 articles about 2-(azetidin-3-yl)pyridine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-tert-butyl 3-(pyridine-2-yl)azetidine-1-carboxylate (206446-39-1) → 2-(azetidin-3-yl)pyridine dihydrochloride (206446-45-9)

Guidance literature:

With hydrogenchloride; In methanol; at 40 ℃; for 3h;

Reference yield: 80.0%

→ 2-(azetidin-3-yl)pyridine dihydrochloride (206446-45-9)

Guidance literature:

Reference yield:

2-bromo-pyridine (109-04-6) → 2-(azetidin-3-yl)pyridine dihydrochloride (206446-45-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Zn, 1,2-dibromoethane, TMSCl / 2.) Pd₂(dba)3, P(2-furyl)3 / 1.) THF, r.t., 45 min, 2.)THF, 65 deg C, 2 h

2: HCl / ethyl acetate / 1 h / 0 °C

With hydrogenchloride; chloro-trimethyl-silane; ethylene dibromide; zinc; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; trifuran-2-yl-phosphane; In ethyl acetate;

DOI:10.1055/s-1998-37503

upstream raw materials:

1-tert-butyl 3-(pyridine-2-yl)azetidine-1-carboxylate

2-bromo-pyridine

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