DL-4-HYDROXY-3-METHOXYMANDELIC ACID

Base Information

• Chemical Name: DL-4-HYDROXY-3-METHOXYMANDELIC ACID
• CAS No.: 2394-20-9
• Molecular Formula: C9H10O5
• Molecular Weight: 198.17300
• Hs Code.: 2918990090
• Mol file: 2394-20-9.mol

Synonyms:DL-4-Hydroxy-3-MethoxyMandelic Acid;

Chemical Property of DL-4-HYDROXY-3-METHOXYMANDELIC ACID

Chemical Property:

• Vapor Pressure: 7.5E-08mmHg at 25°C
• Melting Point: 131-134oC
• Refractive Index: 1.4717 (estimate)
• Boiling Point: 421.3oC at 760 mmHg
• Flash Point: 173.7oC
• PSA: 86.99000
• Density: 1.44g/cm3
• LogP: 0.51880
• Storage Temp.: 2-8°C
• Solubility.: H2O: ~50 mg/mL

Purity/Quality:

97% ^*data from raw suppliers

4-Hydroxy-3-methoxy-DL-mandelic acid, 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DL-4-HYDROXY-3-METHOXYMANDELIC ACID

There total 24 articles about DL-4-HYDROXY-3-METHOXYMANDELIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.7%

2-methoxy-phenol (90-05-1) + Glyoxilic acid (298-12-4) → 4-hydroxy-3-methoxy-mandelic acid (55-10-7,2394-20-9)

Guidance literature:

With C₃₈H₅₈Cl₂CrN₃O₂; sodium hydroxide; In water; at 28 ℃; for 1.5h; pH=11; pH-value; Reagent/catalyst; Temperature; Catalytic behavior;

Reference yield: 88.0%

sodium glyoxylate (2706-75-4) + 2-methoxy-phenol (90-05-1) → 4-hydroxy-3-methoxy-mandelic acid (55-10-7,2394-20-9)

Guidance literature:

2-methoxy-phenol; With sodium hydroxide; In water; at 10 ℃; under 760.051 Torr; pH=11; Inert atmosphere;

sodium glyoxylate; In water; for 34h; under 760.051 Torr; pH-value; Temperature; Time; Inert atmosphere;

DOI:10.1016/j.tet.2013.07.031

Reference yield: 81.4%

2-methoxy-phenol (90-05-1) + Glyoxilic acid (298-12-4) → 2-hydroxy-3-methoxymandelic acid + 2-hydroxy-3-methoxy-1,5-dimandelic acid (73289-78-8) + 4-hydroxy-3-methoxy-mandelic acid (55-10-7,2394-20-9)

Guidance literature:

With sodium hydroxide; succinic acid; In water;

upstream raw materials:

ethyl 4-hydroxy-3-methoxymandelate

2-methoxy-phenol

Glyoxilic acid

chloroform

Downstream raw materials:

α-hydroxy-4-hydroxy-3-methoxybenzeneacetic acid methyl ester

2,2,3,3,3-Pentafluoro-propionic acid [3-methoxy-4-(2,2,3,3,3-pentafluoro-propionyloxy)-phenyl]-(2,2,3,3,3-pentafluoro-propoxycarbonyl)-methyl ester

ethyl 2,3,3-tri-(4-hydroxy-3-methoxyphenyl)propanoate

4,4',4''-(3-hydroxypropane-1,1,2-triyl)tris(2-methoxyphenol)