Carbazomycin A

Base Information

• Chemical Name: Carbazomycin A
• CAS No.: 75139-39-8
• Molecular Formula: C₁₆H₁₇NO₂
• Molecular Weight: 255.316
• DSSTox Substance ID: DTXSID90226111
• Nikkaji Number: J111.105A
• Wikidata: Q77368161
• Metabolomics Workbench ID: 114587
• Mol file: 75139-39-8.mol

Synonyms:3,4-dimethoxy-1,2-dimethylcarbazole;carbazomycin A

Chemical Property of Carbazomycin A

Chemical Property:

• Vapor Pressure: 1.21E-07mmHg at 25°C
• Boiling Point: 443.4°C at 760 mmHg
• Flash Point: 159.4°C
• Density: 1.179g/cm³
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 255.125928785
• Heavy Atom Count: 19
• Complexity: 322

Purity/Quality:

95% ^*data from raw suppliers

CarbazomycinA ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=C(C2=C1NC3=CC=CC=C32)OC)OC)C
• Uses: Carbazomycin A is used in biological studies for antimalarial and antituberculosis activity which are isolated from Streptomyces.

Technology Process of Carbazomycin A

There total 33 articles about Carbazomycin A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

carbazomycin B (75139-38-7) + methyl iodide (74-88-4) → carbazomycin A (75139-39-8)

Guidance literature:

With potassium carbonate; In acetone; Heating;

Reference yield: 92.0%

9-benzyl-3,4-dimethoxy-1,2-dimethyl-9H-carbazole → carbazomycin A (75139-39-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 6h;

DOI:10.1021/acs.orglett.9b01111

Reference yield: 72.0%

dimethyl sulfate (77-78-1) + 3-hydroxy-4-methoxy-1,2-dimethyl-9H-carbazole (125771-80-4) → carbazomycin A (75139-39-8)

Guidance literature:

With sodium hydride; In diethyl ether; for 6h; Ambient temperature;

DOI:10.1002/hlca.19930760709

upstream raw materials:

cyclohexa-1,3-diene

4,5-dimethoxy-2,3-dimethylaniline

dimethyl sulfate

3-hydroxy-4-methoxy-1,2-dimethyl-9H-carbazole