2-[3-(4-Tert-butoxycarbonyl-1-piperazinyl)-2-pyrazinyloxy]ethanol

Base Information

• Chemical Name: 2-[3-(4-Tert-butoxycarbonyl-1-piperazinyl)-2-pyrazinyloxy]ethanol
• CAS No.: 313654-84-1
• Molecular Formula: C15H24N4O4
• Molecular Weight: 324.38
• DSSTox Substance ID: DTXSID10465242
• Wikidata: Q72510437
• Mol file: 313654-84-1.mol

Synonyms:313654-84-1;Tert-butyl 4-[3-(2-hydroxyethoxy)pyrazin-2-yl]piperazine-1-carboxylate;2-[3-(4-TERT-BUTOXYCARBONYL-1-PIPERAZINYL)-2-PYRAZINYLOXY]ETHANOL;tert-Butyl 4-(3-(2-hydroxyethoxy)pyrazin-2-yl)piperazine-1-carboxylate;4-[3-(2-Hydroxyethoxy)-2-pyrazinyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester;A5681;SCHEMBL4003917;DTXSID10465242;ATCSWYASYIDBBB-UHFFFAOYSA-N;2-[3-(4-tert-butoxycarbonyl-1-piperazinyl)-pyrazinyloxy] ethanol;2-[3-(4-tert-butoxycarbonyl-1-piperazinyl)-pyrazinyloxy]ethanol;2-[3-(4-tert-butoxycarbonyl-1piperazinyl)-2-pyrazinyloxy]ethanol;tert-Butyl4-(3-(2-hydroxyethoxy)pyrazin-2-yl)piperazine-1-carboxylate

Chemical Property of 2-[3-(4-Tert-butoxycarbonyl-1-piperazinyl)-2-pyrazinyloxy]ethanol

Chemical Property:

• PSA: 88.02000
• LogP: 0.90770
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 6
• Exact Mass: 324.17975526
• Heavy Atom Count: 23
• Complexity: 380

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N1CCN(CC1)C2=NC=CN=C2OCCO

Technology Process of 2-[3-(4-Tert-butoxycarbonyl-1-piperazinyl)-2-pyrazinyloxy]ethanol

There total 1 articles about 2-[3-(4-Tert-butoxycarbonyl-1-piperazinyl)-2-pyrazinyloxy]ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-[3-(4-tert-butoxycarbonyl-1-piperazinyl)-2-pyrazinyloxy]ethanol (313654-84-1)

Guidance literature:

Reference yield: 81.0%

2-[3-(4-tert-butoxycarbonyl-1-piperazinyl)-2-pyrazinyloxy]ethanol (313654-84-1) + 3-Dimethylaminophenol (99-07-0) → C23H33N5O4 (651046-74-1)

Guidance literature:

With diamide; In tetrahydrofuran; at 20 ℃; for 24h; polymer-bound triphenylphosphine (Fluka)

Reference yield: 58.0%

2-[3-(4-tert-butoxycarbonyl-1-piperazinyl)-2-pyrazinyloxy]ethanol (313654-84-1) + C21H27FN4O4 + 3-fluorophenol (372-20-3) → 1-[2-(3-fluorophenoxy)ethyl]-3-(1-piperazinyl)-2(1H)-pyrazinone

Guidance literature:

2-[3-(4-tert-butoxycarbonyl-1-piperazinyl)-2-pyrazinyloxy]ethanol; 3-fluorophenol; With tributylphosphine; diamide; In tetrahydrofuran; at 20 ℃; for 4h;

C₂₁H₂₇FN₄O₄; With trifluoroacetic acid; In dichloromethane; water; for 0.5h;

Downstream raw materials:

C₂₁H₂₃F₅N₄O₄

tert-butyl 4-{4-[2-(4-cyanophenoxy)ethyl]-3-oxo-3,4-dihydro-2-pyrazinyl}-1-piperazinecarboxylate

C₂₃H₃₃N₅O₄

C₂₁H₂₆FN₅O₆