2-PHENYL-1H-INDOLE-4-CARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 2-PHENYL-1H-INDOLE-4-CARBOXYLIC ACID METHYL ESTER
• CAS No.: 34058-54-3
• Molecular Formula: C16H13NO2
• Molecular Weight: 251.28000
• Mol file: 34058-54-3.mol

Synonyms:methyl 2-phenylindole-4-carboxylate;Methyl-2-phenylindol-4-carboxylat;2-Phenylindol-4-carbonsaeuremethylester;2-phenyl-indole-4-carboxylic acid methyl ester;

Chemical Property of 2-PHENYL-1H-INDOLE-4-CARBOXYLIC ACID METHYL ESTER

Chemical Property:

• PSA: 42.09000
• LogP: 3.62150

Purity/Quality:

99% ^*data from raw suppliers

1H-indole-4-carboxylicacid,2-phenyl-,methylester 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-PHENYL-1H-INDOLE-4-CARBOXYLIC ACID METHYL ESTER

There total 7 articles about 2-PHENYL-1H-INDOLE-4-CARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

methyl 1H-indole-4-carboxylate (39830-66-5) + benzenesufonyl hydrazide (80-17-1) → methyl 2-phenyl-1H-indole-4-carboxylate (34058-54-3)

Guidance literature:

With trifluorormethanesulfonic acid; oxygen; C₃₉H₄₅N₃O₄Pd; In dimethyl sulfoxide; at 60 ℃; for 24h; under 760.051 Torr; Reagent/catalyst; Sealed tube;

DOI:10.1002/aoc.5985

Reference yield: 67.0%

methyl 1H-indole-4-carboxylate (39830-66-5) + phenylboronic acid (98-80-6) → methyl 2-phenyl-1H-indole-4-carboxylate (34058-54-3)

Guidance literature:

With dipotassium peroxodisulfate; sulfuric acid; In methanol; at 20 ℃; for 10h;

DOI:10.1039/c4cy00040d

Reference yield: 41.0%

methyl 2-bromo-3-aminobenzoate (106896-48-4) + 1-(1-phenylvinyl)piperidine (14990-66-0) → methyl 2-phenyl-1H-indole-4-carboxylate (34058-54-3)

Guidance literature:

With triethylamine; palladium diacetate; tris-(o-tolyl)phosphine; In acetonitrile; at 100 ℃; for 20h; sealed tube;

upstream raw materials:

methyl 2-bromo-3-aminobenzoate

1-(1-phenylvinyl)piperidine

methyl 1H-indole-4-carboxylate

Benzenesulfinic acid