2-(1H-IMIDAZOL-2-YL)-BENZONITRILE HCL

Base Information

• Chemical Name: 2-(1H-IMIDAZOL-2-YL)-BENZONITRILE HCL
• CAS No.: 449758-15-0
• Molecular Formula: C10H7N3.ClH
• Molecular Weight: 0.00000
• Mol file: 449758-15-0.mol

Synonyms:

Chemical Property of 2-(1H-IMIDAZOL-2-YL)-BENZONITRILE HCL

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

98% ^*data from raw suppliers

2-(1H-IMIDAZOL-2-YL)BENZONITRILE HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(1H-IMIDAZOL-2-YL)-BENZONITRILE HCL

There total 4 articles about 2-(1H-IMIDAZOL-2-YL)-BENZONITRILE HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2-diethoxy-ethanamine (645-36-3) + 2-cyanobenzimidic acid ethyl ester hydrochloride → 2-(1H-imidazol-2-yl)benzonitrile hydrochloride (449758-15-0) + 2-(1H-imidazol-2-yl)benzoic acid hydrochloride (4278-13-1)

Guidance literature:

2,2-diethoxy-ethanamine; 2-cyanobenzimidic acid ethyl ester hydrochloride; In methanol; at 20 ℃; for 1h;

With sulfuric acid; for 1.5h; Heating;

With hydrogenchloride; In ethanol;

DOI:10.1021/jm030303e

Reference yield:

phthalonitrile (91-15-6) → 2-(1H-imidazol-2-yl)benzonitrile hydrochloride (449758-15-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: HCl gas / CHCl₃ / 336000 h / 0 °C

2.1: methanol / 1 h / 20 °C

2.2: conc. H₂SO₄ / 1.5 h / Heating

2.3: 7.3 g / aq. HCl / ethanol

With hydrogenchloride; In methanol; chloroform;

DOI:10.1021/jm030303e

Reference yield:

→ 2-(1H-imidazol-2-yl)benzonitrile hydrochloride (449758-15-0)

Guidance literature:

upstream raw materials:

2,2-diethoxy-ethanamine

phthalonitrile

Refernces

• 1、 -. "Thrombin inhibitors". . . Retrieved 2008/06/13.