tert-butyl N-(5-amino-2,3,4-trifluorophenyl)carbamate

Base Information

Chemical Name:tert-butyl N-(5-amino-2,3,4-trifluorophenyl)carbamate
CAS No.:535170-19-5
Molecular Formula:C11H13F3N2O2
Molecular Weight:262.232
Hs Code.:
European Community (EC) Number:959-691-0
Mol file:535170-19-5.mol

Synonyms:tert-butyl N-(5-amino-2,3,4-trifluorophenyl)carbamate;535170-19-5;AKOS034062760;EN300-101978;tert-butylN-(5-amino-2,3,4-trifluorophenyl)carbamate;Z1349170205

Suppliers and Price of tert-butyl N-(5-amino-2,3,4-trifluorophenyl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
Tert-butylN-(5-amino-2,3,4-trifluorophenyl)carbamate
2.5g
$ 1799.00

Total 2 raw suppliers

Chemical Property of tert-butyl N-(5-amino-2,3,4-trifluorophenyl)carbamate

Chemical Property:

Melting Point:123 - 124 °C
PSA：64.35000
LogP:3.68730
XLogP3:2.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:262.09291215
Heavy Atom Count:18
Complexity:309

Purity/Quality:

98% ^*data from raw suppliers

Tert-butylN-(5-amino-2,3,4-trifluorophenyl)carbamate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC1=C(C(=C(C(=C1)N)F)F)F

Technology Process of tert-butyl N-(5-amino-2,3,4-trifluorophenyl)carbamate

There total 5 articles about tert-butyl N-(5-amino-2,3,4-trifluorophenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 535170-16-2
tert-butyl 5-nitro-2,3,4-trifluorophenylcarbamate

: 535170-19-5
tert-butyl 5-amino-2,3,4-trifluorophenylcarbamate

Guidance literature:: With hydrogen; palladium; In methanol; at 20 ℃;
DOI:10.1021/jm0205090

Reference yield:

: 197520-71-1
2,3,4-trifluoro-5-nitro-benzoic acid

: 535170-19-5
tert-butyl 5-amino-2,3,4-trifluorophenylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl chloride; DMF / CH₂Cl₂ / 20 °C

2: sodium azide / CH₂Cl₂; dimethylformamide / 20 °C

3: CH₂Cl₂; dimethylformamide / Heating

4: 26 percent / H₂ / palladium black / methanol / 20 °C

With sodium azide; oxalyl dichloride; hydrogen; N,N-dimethyl-formamide; palladium; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0205090

Reference yield:

: 61079-72-9
2,3,4,-trifluorobenzoic acid

: 535170-19-5
tert-butyl 5-amino-2,3,4-trifluorophenylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / KNO₃; conc. H₂SO₄ / 20 °C

2: oxalyl chloride; DMF / CH₂Cl₂ / 20 °C

3: sodium azide / CH₂Cl₂; dimethylformamide / 20 °C

4: CH₂Cl₂; dimethylformamide / Heating

5: 26 percent / H₂ / palladium black / methanol / 20 °C

With sodium azide; oxalyl dichloride; sulfuric acid; hydrogen; potassium nitrate; N,N-dimethyl-formamide; palladium; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0205090