Imidazo[1,2-a]pyridine-2-acetic acid, 6-bromo-, ethyl ester

Base Information

• Chemical Name: Imidazo[1,2-a]pyridine-2-acetic acid, 6-bromo-, ethyl ester
• CAS No.: 59128-04-0
• Molecular Formula: C11H11BrN2O2
• Molecular Weight: 283.12100
• Hs Code.: 2933990090
• Mol file: 59128-04-0.mol

Synonyms:Ethyl 2-(6-bromoimidazo[1,2-a]pyridin-2-yl)acetate;ethyl 2-(6-bromoH-imidazo[1,2-a]pyridin-2-yl)acetate;ethyl2-(6-bromoH-imidazo[1,2-a]pyridin-2-yl)acetate;.ethyl (6-bromoimidazo[1,2-a]pyridine-2-yl)acetate;

Chemical Property of Imidazo[1,2-a]pyridine-2-acetic acid, 6-bromo-, ethyl ester

Chemical Property:

• Melting Point: 55-56℃
• PSA: 43.60000
• Density: 1.54
• LogP: 2.20240

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl (6-bromoimidazo[1,2-a]pyridin-2-yl)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Imidazo[1,2-a]pyridine-2-acetic acid, 6-bromo-, ethyl ester

There total 4 articles about Imidazo[1,2-a]pyridine-2-acetic acid, 6-bromo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-bromo-2-pyridylamine (1072-97-5) + ethyl (2-chloroaceto)acetate (638-07-3) → ethyl 2-(6-bromoimidazolo[1,2-a]pyridin-2-yl)acetate (59128-04-0)

Guidance literature:

In ethanol; for 4h; Reflux; Inert atmosphere;

Reference yield: 70.0%

5-bromo-2-pyridylamine (1072-97-5) + 4-bromoethyl acetoacetate (13176-46-0) → ethyl 2-(6-bromoimidazolo[1,2-a]pyridin-2-yl)acetate (59128-04-0)

Guidance literature:

In acetonitrile; for 96h; Heating / reflux;

Reference yield:

2-amino-4-bromopyridine (84249-14-9) + 4-bromoethyl acetoacetate (13176-46-0) → ethyl 2-(6-bromoimidazolo[1,2-a]pyridin-2-yl)acetate (59128-04-0)

Guidance literature:

With aluminum oxide; In dichloromethane;

upstream raw materials:

5-bromo-2-pyridylamine

4-bromoethyl acetoacetate

ethyl (2-chloroaceto)acetate

2-amino-4-bromopyridine

Downstream raw materials:

2-(6-bromoimidazo[1,2-a]pyridin-2-yl)ethylamine

C₂₁H₂₂N₄

Refernces

• 1、 -. "SUBSTITUTED FUSED HETEROCYCLES AS GPR119 MODULATORS FOR THE TREATMENT OF DIABETES, OBESITY, DYSLIPIDEMIA AND RELATED DISORDERS". Page/Page column 60. . Retrieved 2015/11/17.
• 2、 -. "IMIDAZOLE DERIVATIVES AND METHODS OF USE THEREOF". Page/Page column 17. . Retrieved 2011/06/16.