N-(1H-indol-5-yl)benzamide

Base Information

Chemical Name:N-(1H-indol-5-yl)benzamide
CAS No.:6019-39-2
Molecular Formula:C15H12N2O
Molecular Weight:236.273
Hs Code.:
DSSTox Substance ID:DTXSID301329745
ChEMBL ID:CHEMBL1464276
Mol file:6019-39-2.mol

Synonyms:OAC2;N-(1H-indol-5-yl)benzamide;6019-39-2;5-benzoylaminoindole;N-1h-indol-5-yl-benzamide;OAC-2;5-Benzamidoindole;Maybridge3_002618;Oprea1_121826;MLS000860608;OAC 2;SCHEMBL4761937;CHEMBL1464276;EX-A906;JCAFGYWSIWYMOX-UHFFFAOYSA-N;DTXSID301329745;HMS1438G22;HMS2804E03;BCP15715;MFCD03055811;OAC2, >=97% (HPLC);AKOS013404815;IDI1_014005;AS-57319;HY-12884;SMR000458692;FT-0700340;S5915;EN300-7401519;A914514;J-690331;Z1190790760;6-[(2-Amino-4-pyrimidinyl)oxy]-N-[3-(trifluoromethyl)phenyl]-1-naphthamide

Suppliers and Price of N-(1H-indol-5-yl)benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-(1H-Indol-5-yl)benzamide
250mg
$ 860.00

Tocris
OAC-2 ≥98%(HPLC)
10
$ 81.00

Tocris
OAC-2 ≥98%(HPLC)
50
$ 341.00

Medical Isotopes, Inc.
N-(1H-Indol-5-yl)benzamide
250 mg
$ 1400.00

DC Chemicals
OAC2 >98%
1 g
$ 1300.00

DC Chemicals
OAC2 >98%
250 mg
$ 700.00

DC Chemicals
OAC2 >98%
100 mg
$ 350.00

CSNpharm
OAC2
5mg
$ 38.00

Crysdot
OAC2 98+%
50mg
$ 273.00

Crysdot
OAC2 98+%
100mg
$ 477.00

Total 22 raw suppliers

Chemical Property of N-(1H-indol-5-yl)benzamide

Chemical Property:

Melting Point:165 - 167°C
Boiling Point:364.3±15.0 °C(Predicted)
PKA:13.99±0.43(Predicted)
PSA：44.89000
Density:1.307±0.06 g/cm3(Predicted)
LogP:3.49320
Storage Temp.:Sealed in dry,Room Temperature
Solubility.:DMSO (Slightly), Methanol (Slightly)
XLogP3:2.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:236.094963011
Heavy Atom Count:18
Complexity:299

Purity/Quality:

99%, ^*data from raw suppliers

N-(1H-Indol-5-yl)benzamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C(=O)NC2=CC3=C(C=C2)NC=C3
Description Octamer-binding transcription factor 4 (Oct4) is a transcription factor which, with Sox2, Klf4, and c-Myc, is involved in the reprogramming of somatic cells to produce pluripotent stem cells. OAC2 is an Oct4-activating compound which activates expression through the Oct4 gene promoter. In cells expressing Oct4 with Sox2, Klf4, and c-Myc, OAC2 (1 μM) enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells (iPSCs) from embryonic fibroblasts. The iPSCs developed using OAC2 retain the capacity for pluripotent differentiation, whether evaluated in vitro or in vivo.
Uses N-(1H-Indol-5-yl)benzamide is a octamer-binding transcription factor 4 activating compound that activated Oct4 and Nanog promoters, which are essential regulators of embryonic stem cell (ESC) pluripotency and key to the reprogramming process.

Technology Process of N-(1H-indol-5-yl)benzamide

There total 7 articles about N-(1H-indol-5-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 5192-03-0
5-amino-1H-indole

: 98-88-4
benzoyl chloride

: 6019-39-2
N-(1H-indol-5-yl)benzamide

Guidance literature:: With triethylamine; In tetrahydrofuran;

Reference yield: 63.0%

: 5192-03-0
5-amino-1H-indole

: 65-85-0,8013-63-6
benzoic acid

: 6019-39-2
N-(1H-indol-5-yl)benzamide

Guidance literature:: With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1016/j.ejmech.2016.09.014

Reference yield: 46.0%

: 61650-22-4
N-(pivaloyloxy)benzamide

: 144104-59-6
1H-indole-5-boronic acid

: 6019-39-2
N-(1H-indol-5-yl)benzamide

Guidance literature:: With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; sodium pivalate; In methanol; at 20 ℃; Inert atmosphere; Schlenk technique;
DOI:10.1246/cl.161158