(5-FLUORO-1H-INDAZOL-3-YL)-METHANOL

Base Information

• Chemical Name: (5-FLUORO-1H-INDAZOL-3-YL)-METHANOL
• CAS No.: 518990-02-8
• Molecular Formula: C8H7FN2O
• Molecular Weight: 166.15200
• Mol file: 518990-02-8.mol

Synonyms:

Chemical Property of (5-FLUORO-1H-INDAZOL-3-YL)-METHANOL

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 383.15oC at 760 mmHg
• Flash Point: 185.523oC
• PSA: 48.91000
• Density: 1.469g/cm3
• LogP: 1.19430

Purity/Quality:

98%min ^*data from raw suppliers

(5-Fluoro-1H-indazol-3-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (5-FLUORO-1H-INDAZOL-3-YL)-METHANOL

There total 3 articles about (5-FLUORO-1H-INDAZOL-3-YL)-METHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

methyl 5-fluoro-1H-indazole-3-carboxylate (78155-73-4) → (5-fluoro-1H-indazol-3-yl)methanol (518990-02-8)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; toluene; at -10 - 20 ℃;

Reference yield:

5-fluoro-1H-indazole-3-carboxylic acid (1077-96-9) → (5-fluoro-1H-indazol-3-yl)methanol (518990-02-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 3 h / Reflux

2: diisobutylaluminium hydride / toluene; tetrahydrofuran / -10 - 20 °C

With sulfuric acid; diisobutylaluminium hydride; In tetrahydrofuran; toluene;

Reference yield:

5-fluoro-1H-indole-2,3-dione (443-69-6) → (5-fluoro-1H-indazol-3-yl)methanol (518990-02-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide / water / 1 h / 50 °C

1.2: 1 h / Cooling with ice

1.3: 20 °C / Cooling with ice

2.1: sulfuric acid / 3 h / Reflux

3.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / -10 - 20 °C

With sulfuric acid; diisobutylaluminium hydride; sodium hydroxide; In tetrahydrofuran; water; toluene;

upstream raw materials:

5-fluoro-1H-indazole-3-carboxylic acid

5-fluoro-1H-indole-2,3-dione

methyl 5-fluoro-1H-indazole-3-carboxylate

Downstream raw materials:

5-fluoro-1H-indazole-3-carbaldehyde

Refernces