5-AMINO 1H-INDAZOLE-4-CARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 5-AMINO 1H-INDAZOLE-4-CARBOXYLIC ACID METHYL ESTER
• CAS No.: 78416-43-0
• Molecular Formula: C9H9N3O2
• Molecular Weight: 191.18700
• Hs Code.: 2933990090
• Mol file: 78416-43-0.mol

Synonyms:5-Amino-1H-indazol-4-carbonsaeure-methylester;5-Amino 1H-indazole-4-carboxylic acid methyl ester;

Chemical Property of 5-AMINO 1H-INDAZOLE-4-CARBOXYLIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 408.812oC at 760 mmHg
• Flash Point: 201.043oC
• PSA: 81.00000
• Density: 1.413g/cm3
• LogP: 1.51290
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

5-Amino1H-indazole-4-carboxylicAcidmethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-AMINO 1H-INDAZOLE-4-CARBOXYLIC ACID METHYL ESTER

There total 6 articles about 5-AMINO 1H-INDAZOLE-4-CARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.22%

methanol (67-56-1) + 5-amino-1H-indazole-4-carboxylic acid (78416-42-9) → 5-Amino-1H-indazol-4-carbonsaeure-methylester (78416-43-0)

Guidance literature:

With (diazomethyl)-trimethylsilane; In hexane; toluene; at 20 ℃; for 0.5h;

Reference yield: 64.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 5-amino-1H-indazole-4-carboxylic acid (78416-42-9) → 5-Amino-1H-indazol-4-carbonsaeure-methylester (78416-43-0)

Guidance literature:

In methanol; diethyl ether; water; for 0.5h; Ambient temperature;

DOI:10.1002/cber.19811140506

Reference yield:

1H-indazol-5-ylamine (19335-11-6) → 5-Amino-1H-indazol-4-carbonsaeure-methylester (78416-43-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 89 percent / conc. HCl, hydroxylammoniumchloride, Na₂SO_4.10 H₂O / H₂O / 0.03 h / Heating

2: 63 percent / conc. H₂SO₄ / 0.17 h / 75 °C

3: 92 percent / 10percent NaOH, 10percent aq. H₂O₂ / 0.17 h / 100 °C

4: 64 percent / methanol; H₂O; diethyl ether / 0.5 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; sulfuric acid; hydroxylamine hydrochloride; dihydrogen peroxide; sodium sulfate; In methanol; diethyl ether; water;

DOI:10.1002/cber.19811140506

upstream raw materials:

diazomethane

5-amino-1H-indazole-4-carboxylic acid

1H-indazol-5-ylamine

3,6-Dihydropyrrolo<3,2-e>indazol-7,8-dion

Downstream raw materials:

3,8-Dihydro-9H-pyrazolo<4,3-f>chinazolin-9-on

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