Imidazo[1,2-a]pyridine-2-carboxylic acid, 3-amino-, ethyl ester

Base Information

• Chemical Name: Imidazo[1,2-a]pyridine-2-carboxylic acid, 3-amino-, ethyl ester
• CAS No.: 76157-13-6
• Molecular Formula: C10H11N3O2
• Molecular Weight: 205.21300

Synonyms:ethyl 3-aminoimidazo[1,2-a]pyridine-2-carboxylate;3-amino-2-carbethoxyimidazo<1,2-a>pyridine;3-Amino-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester;

Chemical Property of Imidazo[1,2-a]pyridine-2-carboxylic acid, 3-amino-, ethyl ester

Chemical Property:

• PSA: 69.62000
• LogP: 1.67440

Purity/Quality:

99% ^*data from raw suppliers

Ethyl3-aminoimidazo[1,2-a]pyridine-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Imidazo[1,2-a]pyridine-2-carboxylic acid, 3-amino-, ethyl ester

There total 4 articles about Imidazo[1,2-a]pyridine-2-carboxylic acid, 3-amino-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

potassium cyanide (151-50-8) + ethyl 2-(1H-benzo[d][1,2,3]triazol-1-yl)-2-(pyridin-2-ylamino)acetate (175881-60-4) → 3-amino-2-ethoxycarbonyl imidazo<1,2-a>pyridine (76157-13-6)

Guidance literature:

In ethanol; at 20 ℃; for 2h;

DOI:10.1016/0040-4039(96)00132-3

Reference yield: 70.0%

2-aminopyridine (504-29-0) + glyoxylic acid ethyl ester (924-44-7) + trimethylsilyl cyanide (7677-24-9) → 3-amino-2-ethoxycarbonyl imidazo<1,2-a>pyridine (76157-13-6)

Guidance literature:

2-aminopyridine; glyoxylic acid ethyl ester; In tetrahydrofuran; toluene; at 25 - 27 ℃; for 0.0333333h;

trimethylsilyl cyanide; With 1,4-diaza-bicyclo[2.2.2]octane; In tetrahydrofuran; toluene; at 0 - 120 ℃; for 0.25h; Reagent/catalyst; Solvent; Temperature; Microwave irradiation;

DOI:10.1039/c4ob00882k

Reference yield: 56.6%

ethyl 3-nitroimidazo<1,2-a>pyridine-2-carboxylate (62223-44-3) → 3-amino-2-ethoxycarbonyl imidazo<1,2-a>pyridine (76157-13-6)

Guidance literature:

With sodium hydrogensulfide; In N,N-dimethyl-formamide; for 0.666667h; Ambient temperature;

DOI:10.1021/jo00318a040

upstream raw materials:

ethyl 3-nitroimidazo<1,2-a>pyridine-2-carboxylate

potassium cyanide

ethyl 2-(1H-benzo[d][1,2,3]triazol-1-yl)-2-(pyridin-2-ylamino)acetate

2-aminopyridine

Downstream raw materials:

N-benzylpyrido[1,2-e]purin-4-amine

N-(4-methoxybenzyl)pyrido[1,2-e]purin-4-amine

N-(4-chlorobenzyl)pyrido[1,2-e]purin-4-amine

N-(4-methoxyphenyl)pyrido[1,2-e]purin-4-amine

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