7-Cyano-4-azaindole

Base Information

• Chemical Name: 7-Cyano-4-azaindole
• CAS No.: 1190320-73-0
• Molecular Formula: C8H5N3
• Molecular Weight: 143.14500
• Mol file: 1190320-73-0.mol

Synonyms:7-CYANO-4-AZAINDOLE;

Chemical Property of 7-Cyano-4-azaindole

Chemical Property:

• Boiling Point: 272.6±20.0 °C(Predicted)
• PKA: 12.27±0.40(Predicted)
• PSA: 52.47000
• Density: 1.33±0.1 g/cm3(Predicted)
• LogP: 1.43458

Purity/Quality:

98%min ^*data from raw suppliers

7-Cyano-4-azaindole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Cyano-4-azaindole

There total 6 articles about 7-Cyano-4-azaindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(phenylsulfonyl)-1H-pyrrolo[3,2-b]pyridine-7-carbonitrile → 1H-pyrrolo[3,2-b]pyridine-7-carbonitrile (1190320-73-0)

Guidance literature:

With water; sodium hydroxide; In ethanol; at 80 ℃; for 0.5h;

Reference yield:

1H-pyrrolo[3,2-b]pyridine (272-49-1) → 1H-pyrrolo[3,2-b]pyridine-7-carbonitrile (1190320-73-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Inert atmosphere

2: trichlorophosphate / 80 °C / Inert atmosphere

3: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water / 20 °C / Inert atmosphere

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.5 h / 130 °C / Inert atmosphere; Microwave irradiation

5: sodium hydroxide; water / ethanol / 0.5 h / 80 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; tetra(n-butyl)ammonium hydrogensulfate; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; trichlorophosphate; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

1H-pyrrolo[3,2-b]pyridine 4-oxide (1116136-36-7) → 1H-pyrrolo[3,2-b]pyridine-7-carbonitrile (1190320-73-0)

Guidance literature:

Multi-step reaction with 4 steps

1: trichlorophosphate / 80 °C / Inert atmosphere

2: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water / 20 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.5 h / 130 °C / Inert atmosphere; Microwave irradiation

4: sodium hydroxide; water / ethanol / 0.5 h / 80 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide; trichlorophosphate; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;

upstream raw materials:

1H-pyrrolo[3,2-b]pyridine

1H-pyrrolo[3,2-b]pyridine 4-oxide

7-chloro-1H-pyrrolo[3,2-b]pyridine

Downstream raw materials:

3-iodo-1H-pyrrolo[3,2-b]pyridine-7-carbonitrile

Refernces

• 1、 -. "4-AZAINDOLE DERIVATIVES". Page/Page column 47; 48. . Retrieved 2015/04/22.