tert-Butyl (2-amino-4,5-difluorophenyl)carbamate

Base Information

• Chemical Name: tert-Butyl (2-amino-4,5-difluorophenyl)carbamate
• CAS No.: 1000698-88-3
• Molecular Formula: C11H14F2N2O2
• Molecular Weight: 244.241
• Mol file: 1000698-88-3.mol

Synonyms:tert-butyl (2-amino-4,5-difluoro-phenyl)-carbamate;(2-Amino-4,5-difluoro-phenyl)-carbamic acid tert-butyl ester;tert-Butyl (2-amino-4,5-difluorophenyl)carbamate;

Chemical Property of tert-Butyl (2-amino-4,5-difluorophenyl)carbamate

Chemical Property:

• PSA: 64.35000
• LogP: 3.54820
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl N-(2-amino-4,5-difluorophenyl)carbamate 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl (2-amino-4,5-difluorophenyl)carbamate

There total 3 articles about tert-Butyl (2-amino-4,5-difluorophenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.2%

di-tert-butyl dicarbonate (24424-99-5) + 2-amino-4,5-difluoroaniline (76179-40-3) → (2-amino-4,5-difluoro-phenyl)-carbamic acid tert-butyl ester (1000698-88-3) + C16H22F2N2O4

Guidance literature:

With iodine; In ethanol; at 0 ℃; Product distribution / selectivity;

Reference yield:

tert-butyl 4,5-difluoro-2-nitrophenylcarbamate (1000698-90-7) → (2-amino-4,5-difluoro-phenyl)-carbamic acid tert-butyl ester (1000698-88-3)

Guidance literature:

With ammonium chloride; zinc; In water; N,N-dimethyl-formamide; at 20 - 80 ℃; for 2.5h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 4,5-difluoro-2-nitroaniline (78056-39-0) → (2-amino-4,5-difluoro-phenyl)-carbamic acid tert-butyl ester (1000698-88-3)

Guidance literature:

di-tert-butyl dicarbonate; 4,5-difluoro-2-nitroaniline; With dmap; In tetrahydrofuran; at 20 ℃; for 72h;

With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 48h;

With ammonium chloride; zinc; In water; N,N-dimethyl-formamide; at 20 - 80 ℃; for 2.5h;

upstream raw materials:

di-tert-butyl dicarbonate

4,5-difluoro-2-nitroaniline

2-amino-4,5-difluoroaniline

tert-butyl 4,5-difluoro-2-nitrophenylcarbamate

Downstream raw materials:

2-[2-(3-Chloro-benzyl)-5,6-difluoro-benzoimidazol-1-yl]-2,N-dicyclohexyl-acetamide

N-benzyl-2-cyclohexyl-2-[2-(2,6-dimethoxy-pyridin-3-yl)-5,6-difluoro-benzoimidazol-1-yl]-acetamide

4-{2-cyclohexyl-2-[5,6-difluoro-2-(4-trifluoromethyl-phenyl)-benzoimidazol-1-yl]-acetylamino}-benzoic acid ethyl ester

N-benzyl-2-[2-(4-chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclopropyl-acetamide