tert-butyl 4,5-difluoro-2-nitrophenylcarbamate

Base Information

• Chemical Name: tert-butyl 4,5-difluoro-2-nitrophenylcarbamate
• CAS No.: 1000698-90-7
• Molecular Formula: C₁₁H₁₂F₂N₂O₄
• Molecular Weight: 274.224
• Mol file: 1000698-90-7.mol

Synonyms:tert-butyl 4,5-difluoro-2-nitrophenylcarbamate

Chemical Property of tert-butyl 4,5-difluoro-2-nitrophenylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4,5-difluoro-2-nitrophenylcarbamate

There total 2 articles about tert-butyl 4,5-difluoro-2-nitrophenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

→ tert-butyl 4,5-difluoro-2-nitrophenylcarbamate (1000698-90-7)

Guidance literature:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 4,5-difluoro-2-nitroaniline (78056-39-0) → tert-butyl 4,5-difluoro-2-nitrophenylcarbamate (1000698-90-7)

Guidance literature:

di-tert-butyl dicarbonate; 4,5-difluoro-2-nitroaniline; With dmap; In tetrahydrofuran; at 20 ℃; for 72h;

With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 48h;

With sodium hydroxide; water; In dichloromethane; pH=7;

Reference yield:

tert-butyl 4,5-difluoro-2-nitrophenylcarbamate (1000698-90-7) → (2-amino-4,5-difluoro-phenyl)-carbamic acid tert-butyl ester (1000698-88-3)

Guidance literature:

With ammonium chloride; zinc; In water; N,N-dimethyl-formamide; at 20 - 80 ℃; for 2.5h;

upstream raw materials:

di-tert-butyl dicarbonate

4,5-difluoro-2-nitroaniline

Downstream raw materials:

(2-amino-4,5-difluoro-phenyl)-carbamic acid tert-butyl ester