N-benzyl-5-chloropyridin-2-amine

Base Information

• Chemical Name: N-benzyl-5-chloropyridin-2-amine
• CAS No.: 280116-82-7
• Molecular Formula: C12H11ClN2
• Molecular Weight: 218.686
• Mol file: 280116-82-7.mol

Synonyms:2-PYRIDINAMINE,5-CHLORO-N-(PHENYLMETHYL)-;Benzyl-(5-chlor-[2]pyridyl)-amin;benzyl-(5-chloro-[2]pyridyl)-amine;

Chemical Property of N-benzyl-5-chloropyridin-2-amine

Chemical Property:

• Melting Point: 114-115.2 °C
• Boiling Point: 357.4±27.0 °C(Predicted)
• PKA: 4.88±0.10(Predicted)
• PSA: 24.92000
• Density: 1.251±0.06 g/cm3(Predicted)
• LogP: 3.42010

Purity/Quality:

98% ^*data from raw suppliers

2-Pyridinamine,5-chloro-N-(phenylmethyl)- 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-benzyl-5-chloropyridin-2-amine

There total 6 articles about N-benzyl-5-chloropyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

5-chloro-2-pyridylamine (1072-98-6) + benzyl alcohol (100-51-6,185532-71-2) → N-benzyl-[2-(5-chloropyridyl)]amine (280116-82-7)

Guidance literature:

With sodium hydroxide; at 150 ℃; for 24h; Schlenk technique;

DOI:10.1016/j.tet.2015.11.016

Reference yield: 80.0%

1-[benzyl(5-chloropyridin-2-yl)amino]pyridinium bromide → N-benzyl-[2-(5-chloropyridyl)]amine (280116-82-7)

Guidance literature:

With formic acid; triethylamine; platinum on activated charcoal; In acetonitrile; at 0 - 20 ℃; for 5h;

DOI:10.1016/S0040-4020(00)00084-3

Reference yield: 75.0%

5-chloro-2-pyridylamine (1072-98-6) + toluene (108-88-3,15644-74-3,16713-13-6) → N-benzyl-[2-(5-chloropyridyl)]amine (280116-82-7)

Guidance literature:

With di-tert-butyl peroxide; copper; In neat (no solvent); at 120 ℃; for 12h; Reagent/catalyst; Solvent; Time; Catalytic behavior; Inert atmosphere; Schlenk technique;

DOI:10.1039/d0ob00491j

upstream raw materials:

5-chloro-2-pyridylamine

benzaldehyde

benzyl bromide

pyridinium N-(5'-chloropyridin-2'-yl)aminide