ethyl 2,6-dichloro-3-methylisonicotinate

Base Information

• Chemical Name: ethyl 2,6-dichloro-3-methylisonicotinate
• CAS No.: 137520-99-1
• Molecular Formula: C₉H₉Cl₂NO₂
• Molecular Weight: 234.082
• Hs Code.: 2933399990
• Mol file: 137520-99-1.mol

Synonyms:ethyl 2,6-dichloro-3-methylisonicotinate;2,6-Dichloro-3-methyl-isonicotinic acid ethyl ester

Chemical Property of ethyl 2,6-dichloro-3-methylisonicotinate

Chemical Property:

• Boiling Point: 324.3±37.0 °C(Predicted)
• PKA: -3.66±0.10(Predicted)
• PSA: 39.19000
• Density: 1.320±0.06 g/cm3(Predicted)
• LogP: 2.87350
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

2,6-Dichloro-3-methyl-isonicotinicacidethylester 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2,6-dichloro-3-methylisonicotinate

There total 1 articles about ethyl 2,6-dichloro-3-methylisonicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3,5-dichloro-6-methyl-2(H)-1,4-oxazin-2-one (125849-94-7) + propynoic acid ethyl ester (623-47-2) → 2,6-dichloro-5-methylnicotinic acid ethyl ester (137520-86-6) + 2,6-dichloro-3-methylisonicotinic acid ethyl ester (137520-99-1)

Guidance literature:

at 80 ℃; for 3h; Yields of byproduct given;

DOI:10.1055/s-1991-26570

Reference yield:

2,6-dichloro-3-methylisonicotinic acid ethyl ester (137520-99-1) → 4-(2-cyclohexylaminopyridin-4-yl)-6-piperazin-1-yl-2,3-dihydropyrrolo[3,4-c]pyridin-1-one (1201674-76-1)

Guidance literature:

Multi-step reaction with 5 steps

1: N-Bromosuccinimide; acetic acid; dibenzoyl peroxide / tetrachloromethane / 5 h / 60 °C

2: ammonium hydroxide / tetrahydrofuran / 18 h / 20 °C

3: triethylamine / 1,4-dioxane / 40 h / 120 °C

4: trans-bis(triphenylphosphine)palladium dichloride / toluene / 16 h / 110 °C / Inert atmosphere

5: trifluoroacetic acid / dichloromethane / 2 h

With ammonium hydroxide; N-Bromosuccinimide; acetic acid; triethylamine; trifluoroacetic acid; dibenzoyl peroxide; trans-bis(triphenylphosphine)palladium dichloride; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; dichloromethane; toluene;

Reference yield:

2,6-dichloro-3-methylisonicotinic acid ethyl ester (137520-99-1) → 6-(2-cyclohexylaminopyridin-4-yl)-4-piperazin-1-yl-2,3-dihydropyrrolo[3,4-c]pyridin-1-one (1201674-74-9)

Guidance literature:

Multi-step reaction with 5 steps

1: N-Bromosuccinimide; acetic acid; dibenzoyl peroxide / tetrachloromethane / 5 h / 60 °C

2: ammonium hydroxide / tetrahydrofuran / 18 h / 20 °C

3: triethylamine / 1,4-dioxane / 40 h / 120 °C

4: cesium fluoride / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 18 h / 100 °C

5: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With ammonium hydroxide; N-Bromosuccinimide; acetic acid; triethylamine; cesium fluoride; trifluoroacetic acid; dibenzoyl peroxide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; dichloromethane;

upstream raw materials:

3,5-dichloro-6-methyl-2(H)-1,4-oxazin-2-one

propynoic acid ethyl ester

Downstream raw materials:

4,6-dichloro-2,3-dihydropyrrolo[3,4-c]pyridin-1-one

4-(6-chloro-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester

4-(4-chloro-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)piperazine-1-carboxylic acid tert-butyl ester

4-(2-cyclohexylaminopyridin-4-yl)-6-piperazin-1-yl-2,3-dihydropyrrolo[3,4-c]pyridin-1-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 137520-99-1 ethyl 2,6-dichloro-3-methylisonicotinate

Send

Send

Metric Ton KG G Pound L ML

Send

Send