4-[4-(2-cyclohexylaminopyridin-4-yl)-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl]piperazine-1-carboxylicacid tert-butyl ester

Base Information

• Chemical Name: 4-[4-(2-cyclohexylaminopyridin-4-yl)-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl]piperazine-1-carboxylicacid tert-butyl ester
• CAS No.: 1201676-07-4
• Molecular Formula: C₂₇H₃₆N₆O₃
• Molecular Weight: 492.621
• Mol file: 1201676-07-4.mol

Synonyms:4-[4-(2-cyclohexylaminopyridin-4-yl)-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl]piperazine-1-carboxylicacid tert-butyl ester

Chemical Property of 4-[4-(2-cyclohexylaminopyridin-4-yl)-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl]piperazine-1-carboxylicacid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[4-(2-cyclohexylaminopyridin-4-yl)-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl]piperazine-1-carboxylicacid tert-butyl ester

There total 8 articles about 4-[4-(2-cyclohexylaminopyridin-4-yl)-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl]piperazine-1-carboxylicacid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

cyclohexyl-(4-trimethylstannanylpyridin-2-yl)amine (1201674-98-7) + 4-(4-chloro-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)piperazine-1-carboxylic acid tert-butyl ester (1201676-05-2) → 4-[4-(2-cyclohexylaminopyridin-4-yl)-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl]piperazine-1-carboxylicacid tert-butyl ester (1201676-07-4)

Guidance literature:

trans-bis(triphenylphosphine)palladium dichloride; In toluene; at 110 ℃; for 16h; Inert atmosphere;

Reference yield:

4,6-dichloro-2,3-dihydropyrrolo[3,4-c]pyridin-1-one (1201676-03-0) → 4-[4-(2-cyclohexylaminopyridin-4-yl)-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl]piperazine-1-carboxylicacid tert-butyl ester (1201676-07-4)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / 1,4-dioxane / 40 h / 120 °C

2: trans-bis(triphenylphosphine)palladium dichloride / toluene / 16 h / 110 °C / Inert atmosphere

With triethylamine; trans-bis(triphenylphosphine)palladium dichloride; In 1,4-dioxane; toluene;

Reference yield:

3-bromomethyl-2,6-dichloroisonicotinic acid ethyl ester (1201676-02-9) → 4-[4-(2-cyclohexylaminopyridin-4-yl)-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl]piperazine-1-carboxylicacid tert-butyl ester (1201676-07-4)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium hydroxide / tetrahydrofuran / 18 h / 20 °C

2: triethylamine / 1,4-dioxane / 40 h / 120 °C

3: trans-bis(triphenylphosphine)palladium dichloride / toluene / 16 h / 110 °C / Inert atmosphere

With ammonium hydroxide; triethylamine; trans-bis(triphenylphosphine)palladium dichloride; In tetrahydrofuran; 1,4-dioxane; toluene;

upstream raw materials:

cyclohexyl-(4-trimethylstannanylpyridin-2-yl)amine

4-(4-chloro-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)piperazine-1-carboxylic acid tert-butyl ester

2-cyclohexylamino-4-iodopyridine

4,6-dichloro-2,3-dihydropyrrolo[3,4-c]pyridin-1-one

Downstream raw materials:

4-(2-cyclohexylaminopyridin-4-yl)-6-piperazin-1-yl-2,3-dihydropyrrolo[3,4-c]pyridin-1-one