8-Chloro-3-methylimidazo[1,5-a]pyrazine

Base Information

Chemical Name:8-Chloro-3-methylimidazo[1,5-a]pyrazine
CAS No.:56468-24-7
Molecular Formula:C₇H₆ClN₃
Molecular Weight:167.598
Hs Code.:
European Community (EC) Number:879-229-0
Nikkaji Number:J2.801.067B

Synonyms:8-chloro-3-methylimidazo[1,5-a]pyrazine;56468-24-7;MFCD15006425;SCHEMBL13201541;XWPLDMHOLZHIEB-UHFFFAOYSA-N;AKOS002020017;BS-51860;SY287340;CS-0197288;EN300-203069;Z1263714814

Suppliers and Price of 8-Chloro-3-methylimidazo[1,5-a]pyrazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 8-Chloro-3-methylimidazo[1,5-a]pyrazine

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:167.0250249
Heavy Atom Count:11
Complexity:153

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=NC=C2N1C=CN=C2Cl

Technology Process of 8-Chloro-3-methylimidazo[1,5-a]pyrazine

There total 5 articles about 8-Chloro-3-methylimidazo[1,5-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1040751-47-0
N-((3-chloropyrazin-2-yl)methyl)acetamide

: 56468-24-7
8-chloro-3-methylimidazo[1,5-a]pyrazine

Guidance literature:: With trichlorophosphate; In acetonitrile; at 80 ℃; for 1h;

Reference yield: 70.0%

: 56468-23-6
8-chloro-imidazo[1,5-a]pyrazine

: 74-88-4
methyl iodide

: 56468-24-7
8-chloro-3-methylimidazo[1,5-a]pyrazine

Guidance literature:: 8-chloro-imidazo[1,5-a]pyrazine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 0.25h; regioselective reaction; Inert atmosphere;
DOI:10.1021/ol901889e

Reference yield:

: 771581-15-8
(3-chloro-pyrazin-2-yl)-methylamine

: 56468-24-7
8-chloro-3-methylimidazo[1,5-a]pyrazine

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane / 12 h / 20 °C

2: trichlorophosphate / N,N-dimethyl-formamide; acetonitrile / 0.5 h / 60 °C

With dmap; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;