Imidazo[1,2-a]pyridine-2-carboxylic acid, 7-bromo-, ethyl ester

Base Information

• Chemical Name: Imidazo[1,2-a]pyridine-2-carboxylic acid, 7-bromo-, ethyl ester
• CAS No.: 1187236-18-5
• Molecular Formula: C10H9BrN2O2
• Molecular Weight: 269.098
• Hs Code.: 2933990090
• Mol file: 1187236-18-5.mol

Synonyms:7-Bromo-2-(ethoxycarbonyl)imidazo[1,2-a]pyridine;7-bromoimidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester;

Chemical Property of Imidazo[1,2-a]pyridine-2-carboxylic acid, 7-bromo-, ethyl ester

Chemical Property:

• Melting Point: 188-190℃
• PKA: 1.63±0.50(Predicted)
• PSA: 43.60000
• Density: 1.60±0.1 g/cm3(Predicted)
• LogP: 2.27350
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

Ethyl7-Bromoimidazo[1,2-a]pyridine-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Imidazo[1,2-a]pyridine-2-carboxylic acid, 7-bromo-, ethyl ester

There total 1 articles about Imidazo[1,2-a]pyridine-2-carboxylic acid, 7-bromo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-amino-4-bromopyridine (84249-14-9) + ethyl Bromopyruvate (70-23-5) → 7-bromoimidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester (1187236-18-5)

Guidance literature:

In ethanol; for 8h; Reflux;

Reference yield: 52.0%

7-bromoimidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester (1187236-18-5) → (7-bromoimidazo[1,2-a]pyridin-2-yl)methanol (1187236-21-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at -30 ℃;

Reference yield: 47.0%

Benzophenone imine (1013-88-3) + 7-bromoimidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester (1187236-18-5) → 7-((diphenylmethylene)amino)imidazo[1,2-a]pyridin-2-carboxylic acid ethyl ester

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; for 6h; Reflux; Inert atmosphere;

upstream raw materials:

2-amino-4-bromopyridine

ethyl Bromopyruvate

Downstream raw materials:

(7-bromoimidazo[1,2-a]pyridin-2-yl)methanol

7-bromo-2-chloromethylimidazo[1,2-a]pyridine

(4S,5R)-4-fluoromethyl-5-{4-[2-(methanesulfonylaminomethyl)imidazo[1,2-a]pyridin-7-yl]phenyl}-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

N-{7-[4-((1R,2S)-2-amino-3-fluoro-1-hydroxypropyl)phenyl]imidazo[1,2-a]pyridin-2-ylmethyl}methanesulfonamide

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