7-broMo-2-(chloroMethyl)H-iMidazo[1,2-a]pyridine

Base Information

• Chemical Name: 7-broMo-2-(chloroMethyl)H-iMidazo[1,2-a]pyridine
• CAS No.: 1019023-07-4
• Molecular Formula: C8H6BrClN2
• Molecular Weight: 245.50400
• Mol file: 1019023-07-4.mol

Synonyms:2-CHLORO-7-BROMOBENZOTHIAZOLE;7-BROMO-2-CHLOROBENZO[D]THIAZOLE;7-BROMO-2-CHLOROBENZOTHIAZOLE;

Chemical Property of 7-broMo-2-(chloroMethyl)H-iMidazo[1,2-a]pyridine

Chemical Property:

• PSA: 17.30000
• LogP: 2.83560

Purity/Quality:

98% ^*data from raw suppliers

7-Bromo-2-chloromethylimidazo[1,2-a]pyridine 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-broMo-2-(chloroMethyl)H-iMidazo[1,2-a]pyridine

There total 3 articles about 7-broMo-2-(chloroMethyl)H-iMidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(7-bromoimidazo[1,2-a]pyridin-2-yl)methanol (1187236-21-0) → 7-bromo-2-chloromethylimidazo[1,2-a]pyridine (1019023-07-4)

Guidance literature:

(7-bromoimidazo[1,2-a]pyridin-2-yl)methanol; With thionyl chloride; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere;

With water; sodium hydrogencarbonate; In dichloromethane; at 0 ℃;

Reference yield:

2-amino-4-bromopyridine (84249-14-9) → 7-bromo-2-chloromethylimidazo[1,2-a]pyridine (1019023-07-4)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene / 16 h / 115 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

3: thionyl chloride / dichloromethane / 2 h / 0 - 20 °C

With lithium aluminium tetrahydride; thionyl chloride; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

7-bromoimidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester (1187236-18-5) → 7-bromo-2-chloromethylimidazo[1,2-a]pyridine (1019023-07-4)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

2: thionyl chloride / dichloromethane / 2 h / 0 - 20 °C

With lithium aluminium tetrahydride; thionyl chloride; In tetrahydrofuran; dichloromethane;

upstream raw materials:

(7-bromoimidazo[1,2-a]pyridin-2-yl)methanol

2-amino-4-bromopyridine

7-bromoimidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester

Downstream raw materials:

(4S,5R)-4-fluoromethyl-5-{4-[2-(methanesulfonylaminomethyl)imidazo[1,2-a]pyridin-7-yl]phenyl}-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

N-{7-[4-((1R,2S)-2-amino-3-fluoro-1-hydroxypropyl)phenyl]imidazo[1,2-a]pyridin-2-ylmethyl}methanesulfonamide

2,2-difluoro-N-((1S,2R)-1-fluoromethyl-2-hydroxy-2-{4-[2-(methanesulfonylaminomethyl)imidazo[1,2-a]pyridin-7-yl]phenyl}ethyl)acetamide

Refernces

• 1、 -. "N-AZABICYCLIC CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF". Page/Page column 12. . Retrieved 2011/02/15.