1-(4-fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid

Base Information

Chemical Name:1-(4-fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid
CAS No.:217073-76-2
Molecular Formula:C11H9 F N2 O2
Molecular Weight:220.203
Hs Code.:2933199090
European Community (EC) Number:674-153-2
DSSTox Substance ID:DTXSID50401422
Wikidata:Q82204518
Mol file:217073-76-2.mol

Synonyms:1-(4-fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid;217073-76-2;1-(4-fluorophenyl)-5-methylpyrazole-4-carboxylic acid;MFCD02677737;1H-Pyrazole-4-carboxylic acid, 1-(4-fluorophenyl)-5-methyl-;SCHEMBL1074233;OSM-S-242;AMY7852;DTXSID50401422;KBQWFOMDKNVSAD-UHFFFAOYSA-N;AKOS000131854;AS-5669;BP-13170;BB 0219870;CS-0096782;FT-0605717;EN300-29372;D70952;W-206672;Z235361941;1-(4-Fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylicacid;1-(4-Fluoro-phenyl)-5-methyl-1H-pyrazole-4-c arboxylic acid;1-(4-Fluoro-phenyl)-5-methyl-1H-pyrazole-4-carboxylic acid;1-(4-FLUOROPHENYL)-5-METHYL1HPYRAZOLE-4-CARBOXYLIC ACID

Suppliers and Price of 1-(4-fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-(4-Fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylicAcid
250mg
$ 90.00

Crysdot
1-(4-Fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylicacid 95+%
5g
$ 415.00

Crysdot
1-(4-Fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylicacid 95+%
1g
$ 125.00

Chemenu
1-(4-Fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylicacid 95+%
1g
$ 183.00

Chemenu
1-(4-Fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylicacid 95+%
250mg
$ 79.00

Chemenu
1-(4-Fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylicacid 95+%
5g
$ 593.00

American Custom Chemicals Corporation
1-(4-FLUOROPHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID 95.00%
5G
$ 651.00

American Custom Chemicals Corporation
1-(4-FLUOROPHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID 95.00%
2.5G
$ 542.00

American Custom Chemicals Corporation
1-(4-FLUOROPHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID 95.00%
1G
$ 470.00

Ambeed
1-(4-Fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylicacid 95+%
5g
$ 311.00

Total 20 raw suppliers

Chemical Property of 1-(4-fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid

Chemical Property:

Vapor Pressure:2.47E-06mmHg at 25°C
Melting Point:165 °C
Refractive Index:1.602
Boiling Point:376.4°Cat760mmHg
PKA:3.32±0.25(Predicted)
Flash Point:181.4°C
PSA：55.12000
Density:1.33g/cm³
LogP:2.01800
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:220.06480570
Heavy Atom Count:16
Complexity:267

Purity/Quality:

99%, ^*data from raw suppliers

1-(4-Fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C=NN1C2=CC=C(C=C2)F)C(=O)O

Technology Process of 1-(4-fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid

There total 4 articles about 1-(4-fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 823-85-8
4-fluorophenyhydrazine hydrochloride

: 3788-94-1
2-ethoxymethylene-3-oxobutanoic acid ethyl ester

: 217073-76-2
1-(4-fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid

Guidance literature:: 4-fluorophenyhydrazine hydrochloride; 2-ethoxymethylene-3-oxobutanoic acid ethyl ester; In ethanol; for 3h; Reflux;

With water; sodium hydroxide; In ethanol; for 3h; Reflux;

Reference yield:

: 288252-73-3
ethyl 1-(4-fluorophenyl)-5-methylpyrazole-4-carboxylate

: 217073-76-2
1-(4-fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid

Guidance literature:: With sodium hydroxide; In ethanol; water; for 2h; Heating / reflux;

Reference yield:

: 371-14-2
4-fluorophenylhydrazine

: 217073-76-2
1-(4-fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 2 h / Heating / reflux

2: sodium hydroxide / ethanol; water / 2 h / Heating / reflux

With sodium hydroxide; In ethanol; water;