N-benzyl-2-bromo-3-methoxypropionamide

Base Information

• Chemical Name: N-benzyl-2-bromo-3-methoxypropionamide
• CAS No.: 705283-58-5
• Molecular Formula: C₁₁H₁₄BrNO₂
• Molecular Weight: 272.142
• Mol file: 705283-58-5.mol

Synonyms:N-benzyl-2-bromo-3-methoxypropionamide

Chemical Property of N-benzyl-2-bromo-3-methoxypropionamide

Chemical Property:

Purity/Quality:

99.9% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyl-2-bromo-3-methoxypropionamide

There total 6 articles about N-benzyl-2-bromo-3-methoxypropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.6%

methanol (67-56-1) + N-benzyl-2,3-dibromopropionamide (118790-79-7) → N-benzyl-2-bromo-3-methoxypropionamide (705283-58-5)

Guidance literature:

methanol; N-benzyl-2,3-dibromopropionamide; With sodium hydroxide; at 30 ℃; for 2.5h;

With hydrogenchloride; In water; pH=7;

Reference yield: 73.0%

α-bromo-β-methoxypropanoic acid (65090-78-0) + benzylamine (100-46-9) → N-benzyl-2-bromo-3-methoxypropionamide (705283-58-5)

Guidance literature:

With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -78 - 20 ℃; for 1.75h;

DOI:10.1016/j.bmc.2004.02.043

Reference yield: 51.26%

sodium methylate (124-41-4) + 2,3-dibromopropionic acid ethyl ester (3674-13-3) + benzylamine (100-46-9) → N-benzyl-2-bromo-3-methoxypropionamide (705283-58-5)

Guidance literature:

sodium methylate; 2,3-dibromopropionic acid ethyl ester; With methanol; at -10 - 5 ℃; for 0.25h;

benzylamine; In methanol; at 20 ℃; for 2h;

With hydrogenchloride; In water;

upstream raw materials:

α-bromo-β-methoxypropanoic acid

benzylamine

sodium methylate

2,3-dibromopropionic acid ethyl ester

Downstream raw materials:

N-Benzyl-2-Amino-3-Methoxypropionamide

(R,S)-N-benzyl-2-benzylamino-3-methoxypropionamide

lacosamide

(2S)-2-(acetylamino)-N-benzyl-3-methoxypropanamide

Refernces

• 1、 -. "PROCESS FOR THE PREPARATION OF LACOSAMIDE". . . Retrieved 2012/06/15.
• 2、 Beguin, Cecile,LeTiran, Arnaud,Stables, James P.,Voyksner, Robert D.,Kohn, Harold. "N-Substituted amino acid N′-benzylamides: Synthesis, anticonvulsant, and metabolic activities". . p. 3079 - 3096. Retrieved 2007/10/03.