2-Methyl-D-proline methyl ester hydrochloride

Base Information

• Chemical Name: 2-Methyl-D-proline methyl ester hydrochloride
• CAS No.: 1286768-32-8
• Molecular Formula: C₇H₁₃NO₂*ClH
• Molecular Weight: 179.647
• Mol file: 1286768-32-8.mol

Synonyms:2-Methyl-D-proline methyl ester hydrochloride;methyl (2R)-2-methylpyrrolidine-2-carboxylate hydrochloride;(R)-Methyl 2-methylpyrrolidine-2-carboxylate hydrochloride

Chemical Property of 2-Methyl-D-proline methyl ester hydrochloride

Chemical Property:

• PSA: 38.33000
• LogP: 1.43230

Purity/Quality:

98% ^*data from raw suppliers

methyl(2R)-2-methylpyrrolidine-2-carboxylatehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methyl-D-proline methyl ester hydrochloride

There total 10 articles about 2-Methyl-D-proline methyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + (S)-2-methylpyrrolidine-2-carboxylic acid (42856-71-3) → methyl (S)-2-methylpyrrolidine-2-carboxylate monohydrochloride (220060-08-2,51098-46-5,1286768-32-8)

Guidance literature:

With thionyl chloride; at 0 - 20 ℃; Inert atmosphere;

Reference yield: 100.0%

(3R,7aS)-7a-methyl-3-(trichloromethyl)tetrahydropyrrolo[1,2-c]oxazol-1(3H)-one (220200-88-4) → methyl (S)-2-methylpyrrolidine-2-carboxylate monohydrochloride (220060-08-2,51098-46-5,1286768-32-8)

Guidance literature:

With thionyl chloride; at 0 - 20 ℃; for 0.333333h; Heating / reflux;

Reference yield: 100.0%

methanol (67-56-1) + (3R,7aS)-7a-methyl-3-(trichloromethyl)tetrahydropyrrolo[1,2-c]oxazol-1(3H)-one (220200-88-4) → methyl (S)-2-methylpyrrolidine-2-carboxylate monohydrochloride (220060-08-2,51098-46-5,1286768-32-8)

Guidance literature:

With thionyl chloride; for 3h; Heating;

DOI:10.1016/j.tet.2005.08.026

upstream raw materials:

methanol

(3R,7aS)-7a-methyl-3-(trichloromethyl)tetrahydropyrrolo[1,2-c]oxazol-1(3H)-one

(S)-2-methylpyrrolidine-2-carboxylic acid

(2R,5S)-2-trichloromethyl-1-aza-3-oxabicyclo[3.3.0]octan-4-one

Downstream raw materials:

(R)-methyl 2-methyl-1-(3-(trifluoromethyl)benzyl)pyrrolidine-2-carboxylate

(8aS)-8a-methylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione

(S)-1-tert-butyl 2-methyl 2-methylpyrrolidine-1,2-dicarboxylate

Refernces

• 1、 -. "Chiral amination sulfoxide and preparation method thereof (by machine translation)". Paragraph 0127; 0137-0138. . Retrieved 2020/11/12.
• 2、 Atobe, Masakazu,Blakemore, David C.,Bond, Paul S.,Chan, Ngai S.,De Fusco, Claudia,Downes, Thomas D.,Firth, James D.,Hubbard, Roderick E.,Jones, S. Paul,Klein, Hanna F.,O'Brien, Peter,Roughley, Stephen D.,Vidler, Lewis R.,Waddelove, Laura,Whatton, Maria Ann,Wheldon, Mary C.,Woolford, Alison J.-A.,Wrigley, Gail L.. "Design and Synthesis of 56 Shape-Diverse 3D Fragments". supporting information. . Retrieved 2020/07/13.