Benzaldehyde, 2-[(4-methoxyphenyl)methyl]-

Base Information

• Chemical Name: Benzaldehyde, 2-[(4-methoxyphenyl)methyl]-
• CAS No.: 79364-92-4
• Molecular Formula: C15H14O2
• Molecular Weight: 226.275
• Mol file: 79364-92-4.mol

Synonyms:2-(4-Methoxy-benzyl)-benzaldehyde;

Chemical Property of Benzaldehyde, 2-[(4-methoxyphenyl)methyl]-

Chemical Property:

• PSA: 26.30000
• LogP: 3.09850

Purity/Quality:

2-[(4-methoxyphenyl)methyl]-Benzaldehyde 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzaldehyde, 2-[(4-methoxyphenyl)methyl]-

There total 7 articles about Benzaldehyde, 2-[(4-methoxyphenyl)methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

para-iodoanisole (696-62-8) + 2-methylphenyl aldehyde (529-20-4) → 2-(4-methoxybenzyl)benzaldehyde (79364-92-4)

Guidance literature:

With silver(I) acetate; palladium diacetate; acetic acid; acetic acid hydrazide; In water; at 110 ℃; for 24h; Reagent/catalyst; Temperature; Solvent; Sealed tube;

DOI:10.1021/acs.orglett.6b01170

Reference yield: 81.0%

→ 2-(4-methoxybenzyl)benzaldehyde (79364-92-4)

Guidance literature:

Reference yield: 53.0%

para-iodoanisole (696-62-8) + (E)-2-((2-methylbenzylidene)amino)acetamide → 2-(4-methoxybenzyl)benzaldehyde (79364-92-4)

Guidance literature:

With bis(acetato)bis(triphenylphosphine)palladium⁽⁰⁾; silver trifluoroacetate; butyric acid; In water; at 120 ℃; for 48h; Sealed tube;

DOI:10.1080/00397911.2020.1802759

upstream raw materials:

4-methoxybenzylmagnesium chloride

ortho-bromobenzaldehyde

para-iodoanisole

2-methylphenyl aldehyde

Downstream raw materials:

tert-butyl 2-(hydroxy(2-(4-methoxybenzyl)phenyl)methyl)phenylcarbamate

2-methoxyanthracene

Refernces

• 1、 Lei, Lan,Wu, Ping,Liu, Zhuqing,Lou, Jiang. "Palladium-catalyzed benzylic C(sp3)–H arylation of o-alkylbenzaldehydes". supporting information. . Retrieved 2021/02/16.
• 2、 Wen, Fei,Li, Zheng. "Semicarbazide: A Transient Directing Group for C(sp3)?H Arylation of 2-Methylbenzaldehydes". supporting information. p. 133 - 138. Retrieved 2019/11/28.