AST-1306

Base Information

Chemical Name:AST-1306
CAS No.:897383-62-9
Molecular Formula:C24H18ClFN4O2
Molecular Weight:448.884
Hs Code.:
Mol file:897383-62-9.mol

Synonyms:AST-1306

Suppliers and Price of AST-1306

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
AST-1306
200mg
$ 2470.00

Matrix Scientific
N-(4-(3-Chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)acrylamide 95%
100mg
$ 3108.00

Matrix Scientific
N-(4-(3-Chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)acrylamide 95%
1g
$ 7178.00

Crysdot
AST-1306 98+%
10mg
$ 215.00

Crysdot
AST-1306 98+%
5mg
$ 123.00

Crysdot
AST-1306 98+%
50mg
$ 680.00

Chemenu
N-(4-(3-Chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)acrylamide 98%
50mg
$ 636.00

Chemenu
N-(4-(3-Chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)acrylamide 98%
10mg
$ 201.00

Biorbyt Ltd
AST-1306 >98%
1000 mg
$ 4469.30

Biorbyt Ltd
AST-1306 >98%
100 mg
$ 1133.90

Total 29 raw suppliers

Chemical Property of AST-1306

Chemical Property:

Boiling Point:655℃
PKA:12.16±0.43(Predicted)
Flash Point:350℃
PSA：79.63000
Density:1.395
LogP:6.59190
Solubility.:≥22.45 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH

Purity/Quality:

99%, ^*data from raw suppliers

AST-1306 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses AST-1306 is a novel irreversible inhibitor of EGFR and ErbB4 with IC50 of 0.5 nM and 0.8 nM, respectively. AST-1306 is a selective irreversible inhibitor of the epidermal growth factor receptor (EGFR) 1 and 2. Studies show that AST-1306 inhibited the enzymatic activities of wild-type EGF) and ErbB2 as well as EGFR resistant mutant in both cell-free and cell-based systems. AST-1306 was more effective in inhibiting tumors with ErbB2-overexpressing cells than EGFR-overexpressing tumor.

Technology Process of AST-1306

There total 5 articles about AST-1306 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 845271-71-8
N⁴-[3-chloro-4-(3-fluoro-benzyloxy)-phenyl]-quinazoline-4,6-diamine

: 814-68-6,25189-84-8
acryloyl chloride

: 897383-62-9
N-(4-(4-(3-fluorobenzyloxy)-3-chlorophenylamino)quinazolin-6-yl)acrylamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

Reference yield: 50.0%

: 897383-62-9
N-(4-(4-(3-fluorobenzyloxy)-3-chlorophenylamino)quinazolin-6-yl)acrylamide

Guidance literature:

Reference yield:

: 19815-16-8
4-chloro-6-nitro-quinazoline

: 897383-62-9
N-(4-(4-(3-fluorobenzyloxy)-3-chlorophenylamino)quinazolin-6-yl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: isopropyl alcohol / 3 h / Reflux

2: acetic acid; iron / methanol / 2.5 h / 85 °C

3: triethylamine / tetrahydrofuran / 20 °C / Cooling with ice

With iron; acetic acid; triethylamine; In tetrahydrofuran; methanol; isopropyl alcohol;