O-dealky-27,28-dihydrodiolallitinib

Base Information

• Chemical Name: O-dealky-27,28-dihydrodiolallitinib
• CAS No.: 1636145-47-5
• Molecular Formula: C₁₇H₁₅ClN₄O₄
• Molecular Weight: 374.783
• Mol file: 1636145-47-5.mol

Synonyms:O-dealky-27,28-dihydrodiolallitinib

Chemical Property of O-dealky-27,28-dihydrodiolallitinib

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O-dealky-27,28-dihydrodiolallitinib

There total 2 articles about O-dealky-27,28-dihydrodiolallitinib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

O-dealkylallitinib + citric acid (77-92-9,906507-37-7) → O-dealky-27,28-dihydrodiolallitinib (1636145-47-5)

Guidance literature:

With potassium osmate(VI); 4-methylmorpholine N-oxide; In water; acetone; at 20 ℃; for 48h;

DOI:10.1124/dmd.113.056341

Reference yield:

N-(4-(4-(3-fluorobenzyloxy)-3-chlorophenylamino)quinazolin-6-yl)acrylamide (897383-62-9) → O-dealky-27,28-dihydrodiolallitinib (1636145-47-5)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum (III) chloride / acetone / 10 h / 20 °C

2: potassium osmate(VI); 4-methylmorpholine N-oxide / acetone; water / 48 h / 20 °C

With aluminum (III) chloride; potassium osmate(VI); 4-methylmorpholine N-oxide; In water; acetone;

DOI:10.1124/dmd.113.056341

upstream raw materials:

N-(4-(4-(3-fluorobenzyloxy)-3-chlorophenylamino)quinazolin-6-yl)acrylamide

citric acid

Refernces