5-Methoxy-2-phenoxyaniline

Base Information

• Chemical Name: 5-Methoxy-2-phenoxyaniline
• CAS No.: 76838-72-7
• Molecular Formula: C13H13NO2
• Molecular Weight: 215.252
• Hs Code.: 2922299090
• DSSTox Substance ID: DTXSID10429440
• Nikkaji Number: J2.156.079K
• Wikidata: Q82242473
• Mol file: 76838-72-7.mol

Synonyms:5-METHOXY-2-PHENOXYANILINE;76838-72-7;Benzenamine,5-methoxy-2-(phenylmethoxy)-;3-amino-4-phenoxyanisole;5-methoxy-2-phenoxyphenylamine;5-methoxy-2-phenoxybenzenamine;SCHEMBL9271567;DTXSID10429440;UOGZDMKXQVZVGO-UHFFFAOYSA-N;BDA83872;AKOS022173295;CS-0370559

Chemical Property of 5-Methoxy-2-phenoxyaniline

Chemical Property:

• Melting Point: 109-111 °C(Solv: benzene (71-43-2); ligroine (8032-32-4))
• Boiling Point: 336.0±32.0 °C(Predicted)
• PKA: 3.72±0.10(Predicted)
• PSA: 44.48000
• Density: 1.155±0.06 g/cm3(Predicted)
• LogP: 3.65090
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 215.094628657
• Heavy Atom Count: 16
• Complexity: 204

Purity/Quality:

98% ^*data from raw suppliers

5-Methoxy-2-phenoxyaniline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)OC2=CC=CC=C2)N

Technology Process of 5-Methoxy-2-phenoxyaniline

There total 8 articles about 5-Methoxy-2-phenoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

5-methoxy-1-nitro-2-phenoxybenzene (84594-95-6) → 5-methoxy-2-phenoxyaniline (76838-72-7)

Guidance literature:

With hydrogen; In methanol; at 90 ℃; for 4h; under 15001.5 Torr; Temperature; Pressure; Molecular sieve; Autoclave;

Reference yield: 64.0%

→ 5-methoxy-2-phenoxyaniline (76838-72-7)

Guidance literature:

With iron; acetic acid; In ethanol; at 70 ℃; for 4h; Inert atmosphere;

Reference yield:

bromobenzene (108-86-1,52753-63-6) + 2-amino-4-methoxyphenol (20734-76-3) → 5-methoxy-2-phenoxyaniline (76838-72-7)

Guidance literature:

2-amino-4-methoxyphenol; With potassium hydroxide; at 160 ℃; for 3.5h;

bromobenzene; With copper; at 180 - 200 ℃; for 2h; Temperature;

upstream raw materials:

5-methoxy-1-nitro-2-phenoxybenzene

2-chloro-5-methoxynitrobenzene

phenol

4-bromo-3-nitroanizole

Downstream raw materials:

4-phenoxy-3-trifluoromethylsulfonylaminoanisole

1-Benzoyl-3-(5-methoxy-2-phenoxy-phenyl)-thiourea

2-Brom-4-methoxy-diphenylaether

N-(5-methoxy-2-phenoxyphenyl)methanesulfonamide