(4R)-4-AMINO-4-PHENYLBUTANOIC ACID

Base Information

• Chemical Name: (4R)-4-AMINO-4-PHENYLBUTANOIC ACID
• CAS No.: 201863-97-0
• Molecular Formula: C10H13NO2
• Molecular Weight: 179.22
• Mol file: 201863-97-0.mol

Synonyms:(4R)-4-AMINO-4-PHENYLBUTANOIC ACID;(R)-4-AMINO-4-PHENYLBUTANOIC ACID;(R)-4-Amino-4-phenyl-butyric acid

Chemical Property of (4R)-4-AMINO-4-PHENYLBUTANOIC ACID

Chemical Property:

• Vapor Pressure: 5.84E-05mmHg at 25°C
• Boiling Point: 332.3°C at 760 mmHg
• Flash Point: 154.8°C
• Density: 1.161g/cm³
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

(R)-4-Amino-4-phenylbutanoic acid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R)-4-AMINO-4-PHENYLBUTANOIC ACID

There total 23 articles about (4R)-4-AMINO-4-PHENYLBUTANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-hydroxyimino-4-phenylbutanoic acid (87252-81-1) → (rac)-4-amino-4-phenylbutanoic acid (1011-60-5,201863-97-0)

Guidance literature:

With ammonia; sodium; In methanol; for 2h;

Reference yield: 38.3%

succinylbenzene (2051-95-8) → (S)-4-amino-4-phenylbutanoic acid (201863-97-0)

Guidance literature:

With (S)-1-phenyl-ethylamine; pyridoxal 5'-phosphate; ω-transaminase from Polaromonas sp.; piruvate; In aq. phosphate buffer; at 37 ℃; for 24h; pH=7.0; Reagent/catalyst; Resolution of racemate; Enzymatic reaction;

DOI:10.1039/c3cc44864a

Reference yield:

(rac)-4-amino-4-phenylbutanoic acid (1011-60-5,201863-97-0) → (R)-4-amino-4-phenylbutanoic acid (201863-97-0) + succinylbenzene (2051-95-8)

Guidance literature:

With pyridoxal 5'-phosphate; ω-transaminase from Polaromonas sp.; piruvate; In dimethyl sulfoxide; for 24h; pH=7.0; Reagent/catalyst; Resolution of racemate; Enzymatic reaction;

DOI:10.1039/c3cc44864a

upstream raw materials:

4-phenyl-but-3-enoic acid amide

4-hydroxyimino-4-phenylbutanoic acid

(+/-)-5-phenyl-2-pyrrolidinone

4-phenyl-4-phenylhydrazono-crotonic acid

Downstream raw materials:

4-Amino-4-phenyl-butyric acid hexyl ester; hydrochloride

5-(4-nitrophenyl)pyrrolidin-2-one

4-Amino-4-phenyl-butyric acid octyl ester; hydrochloride

Refernces

• 1、 Kim, Geon-Hee,Jeon, Hyunwoo,Khobragade, Taresh P.,Patil, Mahesh D.,Sung, Sihyong,Yoon, Sanghan,Won, Yumi,Sarak, Sharad,Yun, Hyungdon. "Glutamate as an Efficient Amine Donor for the Synthesis of Chiral β- and γ-Amino Acids Using Transaminase". . p. 1437 - 1440. Retrieved 2019/02/06.
• 2、 Nilsson, Bjoern M.,Vargas, Hugo M.,Ringdahl, Bjoern,Hacksell, Uli. "Phenyl-Substituted Analogues of Oxotremorine as Muscarinic Antagonists". . p. 285 - 294. Retrieved 2007/10/02.