2-fluoro-6-hydroxy-3-(pyridin-2-yl)benzonitrile

Base Information

• Chemical Name: 2-fluoro-6-hydroxy-3-(pyridin-2-yl)benzonitrile
• CAS No.: 1308400-88-5
• Molecular Formula: C₁₂H₇FN₂O
• Molecular Weight: 214.199
• Mol file: 1308400-88-5.mol

Synonyms:2-fluoro-6-hydroxy-3-(pyridin-2-yl)benzonitrile

Chemical Property of 2-fluoro-6-hydroxy-3-(pyridin-2-yl)benzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-fluoro-6-hydroxy-3-(pyridin-2-yl)benzonitrile

There total 4 articles about 2-fluoro-6-hydroxy-3-(pyridin-2-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

2,6-difluoro-3-(pyridine-2-yl)benzonitrile (883106-18-1) → 6-fluoro-2-hydroxy-3-(pyridin-2-yl)benzonitrile (1308400-82-9) + 2-fluoro-6-hydroxy-3-(pyridin-2-yl)benzonitrile (1308400-88-5) + 2,6-difluoro-3-(pyridin-2-yl)benzamide (1308400-83-0)

Guidance literature:

2,6-difluoro-3-(pyridine-2-yl)benzonitrile; With potassium hydroxide; In 1,4-dioxane; water; for 1h; Reflux;

With acetic acid; In water;

DOI:10.1021/jo200357e

Reference yield:

2,4-difluoro-3-cyanophenylboronic acid (871940-31-7) → 2-fluoro-6-hydroxy-3-(pyridin-2-yl)benzonitrile (1308400-88-5) + 2,6-difluoro-3-(pyridin-2-yl)benzamide (1308400-83-0)

Guidance literature:

Multi-step reaction with 3 steps

1: dimethyl sulfoxide; toluene / 4 h / Reflux

2: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate / 1,4-dioxane; water / 20 h / 65 °C / Inert atmosphere

3: potassium hydroxide / 1,4-dioxane; water / 1 h / Reflux

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate; potassium hydroxide; In 1,4-dioxane; water; dimethyl sulfoxide; toluene;

DOI:10.1021/jo200357e

Reference yield:

2,6-difluoro-3-(6-methyl-4,8-dioxo-1,3,6,2-dioxazaborocan-2-yl)benzonitrile (1308400-81-8) → 2-fluoro-6-hydroxy-3-(pyridin-2-yl)benzonitrile (1308400-88-5) + 2,6-difluoro-3-(pyridin-2-yl)benzamide (1308400-83-0)

Guidance literature:

Multi-step reaction with 2 steps

1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate / 1,4-dioxane; water / 20 h / 65 °C / Inert atmosphere

2: potassium hydroxide / 1,4-dioxane; water / 1 h / Reflux

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate; potassium hydroxide; In 1,4-dioxane; water;

DOI:10.1021/jo200357e

upstream raw materials:

2,4-difluoro-3-cyanophenylboronic acid

2,6-difluoro-3-(6-methyl-4,8-dioxo-1,3,6,2-dioxazaborocan-2-yl)benzonitrile

2,6-difluoro-3-(pyridine-2-yl)benzonitrile

2,6 difluorobenzonitrile

Downstream raw materials:

6-[4-(9H-carbazol-9-yl)butoxy]-2-fluoro-3-(pyridin-2-yl)-benzonitrile

2-fluoro-6-(octyloxy)-3-(pyridin-2-yl)benzonitrile