2-(2-Bromothiophen-3-yl)ethanamine

Base Information

• Chemical Name: 2-(2-Bromothiophen-3-yl)ethanamine
• CAS No.: 893421-71-1
• Molecular Formula: C6H8BrNS
• Molecular Weight: 206.10342
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID40695853
• Wikidata: Q82625199
• Mol file: 893421-71-1.mol

Synonyms:2-(2-bromothiophen-3-yl)ethanamine;893421-71-1;2-(2-bromothiophen-3-yl)ethan-1-amine;2-(2-BROMO-THIOPHEN-3-YL)-ETHYLAMINE;SCHEMBL2985299;DTXSID40695853;PYQXWZQETVCFSI-UHFFFAOYSA-N;SB39675;CS-0106554;EN300-1067566

Chemical Property of 2-(2-Bromothiophen-3-yl)ethanamine

Chemical Property:

• PSA: 54.26000
• LogP: 2.71210
• Storage Temp.: 2-8°C
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 204.95608
• Heavy Atom Count: 9
• Complexity: 89.1

Purity/Quality:

NLT 98% ^*data from raw suppliers

2-(2-Bromo-thiophen-3-yl)-ethylamine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CSC(=C1CCN)Br

Technology Process of 2-(2-Bromothiophen-3-yl)ethanamine

There total 2 articles about 2-(2-Bromothiophen-3-yl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(thiophen-3-yl)ethan-1-amine hydrochloride (34843-84-0) → 2-(2-bromothiophen-3-yl)ethylamine (893421-71-1)

Guidance literature:

2-(thiophen-3-yl) ethanamine hydrochloride; With bromine; acetic acid; at 0 - 20 ℃;

With sodium hydroxide; In water;

Reference yield:

(thiophen-3-yl)acetonitrile (13781-53-8) → 2-(2-bromothiophen-3-yl)ethylamine (893421-71-1)

Guidance literature:

Multi-step reaction with 2 steps

1: borane-THF / tetrahydrofuran / 20 °C / Inert atmosphere; Reflux

2: bromine; acetic acid / 0 - 20 °C

With borane-THF; bromine; acetic acid; In tetrahydrofuran;

Reference yield:

(3,4-Dimethoxyphenyl)acetic acid (93-40-3) + 2-(2-bromothiophen-3-yl)ethylamine (893421-71-1) → N-[2-(2-bromothiophen-3-yl)ethyl]-2-(3,4-dimethoxyphenyl)acetamide (1394174-89-0)

Guidance literature:

(3,4-Dimethoxyphenyl)acetic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.0833333h;

2-(2-bromothiophen-3-yl)ethylamine; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 6h;

upstream raw materials:

2-(thiophen-3-yl)ethan-1-amine hydrochloride

(thiophen-3-yl)acetonitrile

Downstream raw materials:

N-[2-(2-bromothiophen-3-yl)ethyl]-2-(3,4-dimethoxyphenyl)acetamide

rac-1-bromo-4-(3,4-dimethoxybenzyl)-4,5,6,7-tetrahydrothieno[3,4-c]pyridine

C₁₆H₁₆BrNO₂S

Refernces