3-(cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine

Base Information

Chemical Name:3-(cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
CAS No.:1254977-87-1
Molecular Formula:C22H23F3N4
Molecular Weight:400.447
Hs Code.:
Mol file:1254977-87-1.mol

Synonyms:3-(cyclopropylmethyl)-7-(4-phenyl-1-piperidinyl)-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine;4-[4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol;4-(4-Fluorophenyl)-2-(4-hydroxy-1-butynyl)-1-(3-phenylpropyl)-5-(pyridin-4-yl)imidazole;4-(4-Fluorophenyl)-2-(4-hydroxybutyn-1-yl)-1-(3-phenylpropyl)-5-(pyridin-4-yl)imidazole;3-(cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;1-[(5-CHLORO-1H-INDOL-2-YL)CARBONYL]-4-METHYL-PIPERAZINE;4-(4-Fluorophenyl)-2-(4-hydroxybutyn-1-yl)-1-(3-phenylpropyl)-5-(4-pyridyl)imidazole;(5-chloro-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)methanone;4-(4-fluorophenyl)-2-(4-hydroxy-1-butynyl)-1-(3-phenylpropyl)-5-(4-pyridyl)imidazole;

Suppliers and Price of 3-(cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
JNJ42153605 >98%
250 mg
$ 1000.00

DC Chemicals
JNJ42153605 >98%
1 g
$ 2000.00

ChemScene
JNJ-42153605 99.00%
100mg
$ 1140.00

ChemScene
JNJ-42153605 99.00%
5mg
$ 180.00

ChemScene
JNJ-42153605 99.00%
10mg
$ 264.00

ChemScene
JNJ-42153605 99.00%
50mg
$ 792.00

Cayman Chemical
JNJ-42153605
25mg
$ 508.00

Cayman Chemical
JNJ-42153605
10mg
$ 232.00

Cayman Chemical
JNJ-42153605
5mg
$ 131.00

Cayman Chemical
JNJ-42153605
1mg
$ 29.00

Total 8 raw suppliers

Chemical Property of 3-(cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine

Chemical Property:

PKA:3.07±0.30(Predicted)
PSA：33.43000
Density:1.38±0.1 g/cm3(Predicted)
LogP:5.14960

Purity/Quality:

99%, ^*data from raw suppliers

JNJ42153605 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description JNJ-42153605 is a positive allosteric modulator of metabotropic glutamate receptor 2 (mGluR2; EC50 = 17 nM in CHO cells expressing the human receptor). In vivo, JNJ-42153605 (3 mg/kg) inhibits mGluR2-mediated rapid eye movement (REM) sleep in rats. It also reverses phencyclidine-induced hyperlocomotion in mice (ED50 = 5.4 mg/kg).

Technology Process of 3-(cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine

There total 4 articles about 3-(cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 771-99-3
4-phenylpiperidine

: 1254981-30-0
7-chloro-3-(cyclopropylmethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine

: 1254977-87-1
NJ-42153605

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 180 ℃; for 0.333333h; Microwave irradiation;
DOI:10.1021/jm3010724

Reference yield:

: 1254981-27-5
4-(benzyloxy)-2-chloro-3-(trifluoromethyl)pyridine

: 1254977-87-1
NJ-42153605

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrazine hydrate / 1,4-dioxane / 0.5 h / 160 °C / Microwave irradiation

2.1: triethylamine / dichloromethane / 1 h / 20 °C

2.2: 150 °C / Microwave irradiation

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.33 h / 180 °C / Microwave irradiation

With hydrazine hydrate; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1021/jm3010724

Reference yield:

: 1186194-98-8
2,4-dichloro-3-(trifluoromethyl)pyridine

: 1254977-87-1
NJ-42153605

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 1 h / 0 - 20 °C

2.1: hydrazine hydrate / 1,4-dioxane / 0.5 h / 160 °C / Microwave irradiation

3.1: triethylamine / dichloromethane / 1 h / 20 °C

3.2: 150 °C / Microwave irradiation

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.33 h / 180 °C / Microwave irradiation

With sodium hydride; hydrazine hydrate; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1021/jm3010724