Methyl 7-Nitro-1,4-benzodioxane-6-carboxylate

Base Information

• Chemical Name: Methyl 7-Nitro-1,4-benzodioxane-6-carboxylate
• CAS No.: 52791-03-4
• Molecular Formula: C10H9NO6
• Molecular Weight: 239
• Mol file: 52791-03-4.mol

Synonyms:Methyl 7-Nitro-1,4-benzodioxane-6-carboxylate;Methyl7-Nitro-1,4-benzodioxane-6-carboxylate;

Chemical Property of Methyl 7-Nitro-1,4-benzodioxane-6-carboxylate

Chemical Property:

• Boiling Point: 363.0±42.0 °C(Predicted)
• PSA: 90.58000
• Density: 1.422±0.06 g/cm3(Predicted)
• LogP: 1.67580

Purity/Quality:

97% ^*data from raw suppliers

Methyl7-nitro-2,3-dihydrobenzo[b][1,4]dioxine-6-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 7-Nitro-1,4-benzodioxane-6-carboxylate

There total 4 articles about Methyl 7-Nitro-1,4-benzodioxane-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid methyl ester (20197-75-5) → 7-nitro-2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid methyl ester (52791-03-4)

Guidance literature:

With nitric acid; acetic acid; at 20 ℃;

Reference yield:

3,4-dihydroxybenzoic acid methyl ester (2150-43-8) → 7-nitro-2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid methyl ester (52791-03-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide; ethanol

2: acetic acid; nitric acid

With potassium hydroxide; ethanol; nitric acid; acetic acid;

Reference yield:

3,4-Dihydroxybenzoic acid (99-50-3) → 7-nitro-2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid methyl ester (52791-03-4)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / 4 h / Reflux

2: potassium hydroxide / methanol / 30 h / Reflux

3: nitric acid / water; acetic acid / 20 °C

With sulfuric acid; nitric acid; potassium hydroxide; In methanol; water; acetic acid;

upstream raw materials:

2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid methyl ester

3,4-dihydroxybenzoic acid methyl ester

2,3-dihydro-1,4-benzodioxin-6-carboxylic acid

3,4-Dihydroxybenzoic acid

Downstream raw materials:

7-amino-2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid methyl ester

7-amino-2,3-dihydrobenzo[b][1,4]dioxine-6-carboxylic acid