(1s,3s)-3-(benzyloxy)cyclobutan-1-ol

Base Information

• Chemical Name: (1s,3s)-3-(benzyloxy)cyclobutan-1-ol
• CAS No.: 233276-35-2
• Molecular Formula: C11H14O2
• Molecular Weight: 178.231
• Mol file: 233276-35-2.mol

Synonyms:(1s,3s)-3-(benzyloxy)cyclobutan-1-ol;(1s,3s)-3-(benzyloxy)cyclobutanol

Chemical Property of (1s,3s)-3-(benzyloxy)cyclobutan-1-ol

Chemical Property:

• PSA: 29.46000
• LogP: 1.72650
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%min ^*data from raw suppliers

(1s,3s)-3-Benzyloxycyclobutanol 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1s,3s)-3-(benzyloxy)cyclobutan-1-ol

There total 7 articles about (1s,3s)-3-(benzyloxy)cyclobutan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-benzyloxy cyclobutanone (30830-27-4) → (±)-cis-(1s,3s)-3-(benzyloxy)cyclobutan-1-ol (233276-35-2)

Guidance literature:

With sodium tetrahydroborate; ethanol; at 0 ℃; for 3h;

Reference yield: 94.0%

3-(benzyloxy)cyclobutyl 4-nitrobenzoate → (±)-cis-(1s,3s)-3-(benzyloxy)cyclobutan-1-ol (233276-35-2)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; at 20 ℃; for 1h;

Reference yield:

3-benzyloxy cyclobutanone (30830-27-4) + L-Selectride → (±)-cis-(1s,3s)-3-(benzyloxy)cyclobutan-1-ol (233276-35-2)

Guidance literature:

In tetrahydrofuran; at -78 - 20 ℃; for 2h;

upstream raw materials:

3-benzyloxy cyclobutanone

benzyl bromide

(2-bromo-1-bromomethylethoxymethyl)benzene

3-(phenylmethoxy)cyclobutan-1-ol

Downstream raw materials:

trans-3-(fluorocyclobutyl) benzyl ether

(1s,3s)-3-(benzyloxy)cyclobutyl 4-methylbenzenesulfonate

methyl O-[trans-3-(benzyloxy)cyclobutyl]-N-(tert-butoxycarbonyl)-L-tyrosine

methyl O-[trans-3-(benzyloxy)cyclobutyl]-N-(tert-butoxycarbonyl)-D-tyrosine

Refernces

• 1、 -. "CDPK1 INHIBITORS, COMPOSITIONS, AND METHODS RELATED THERETO". Paragraph 0287-0289. . Retrieved 2021/11/13.
• 2、 -. "BTK inhibitor and preparation method and pharmaceutical application thereof". Paragraph 0917-0925. . Retrieved 2020/12/14.