4-PyriMidinecarboxylic acid, 2-aMino-, Methyl ester

Base Information

• Chemical Name: 4-PyriMidinecarboxylic acid, 2-aMino-, Methyl ester
• CAS No.: 2164-66-1
• Molecular Formula: C6H7N3O2
• Molecular Weight: 153.14
• Hs Code.: 2933599090
• Mol file: 2164-66-1.mol

Synonyms:4-PyriMidinecarboxylic acid, 2-aMino-, Methyl ester;Methyl 2-aMinopyriMidine-4-carboxylate

Chemical Property of 4-PyriMidinecarboxylic acid, 2-aMino-, Methyl ester

Chemical Property:

• Melting Point: 230 °C
• Boiling Point: 344.2±34.0 °C(Predicted)
• PKA: 2.10±0.10(Predicted)
• PSA: 78.83000
• Density: 1.319±0.06 g/cm3(Predicted)
• LogP: -0.22450
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-aminopyrimidine-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-PyriMidinecarboxylic acid, 2-aMino-, Methyl ester

There total 2 articles about 4-PyriMidinecarboxylic acid, 2-aMino-, Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

methyl 4-n-butoxy-2-oxo-3-butenoate (502164-18-3) + guanidine hydrochloride (50-01-1) → methyl 2-aminopyrimidine-4-carboxylate (2164-66-1)

Guidance literature:

With triethylamine; In propiononitrile; at 100 ℃; for 4h;

Reference yield:

→ methyl 2-aminopyrimidine-4-carboxylate (2164-66-1)

Guidance literature:

2-Amino-pyrimidin-carbonsaeure-(4), ether. Diazomethan, DMF;

Reference yield: 66.0%

methyl 2-aminopyrimidine-4-carboxylate (2164-66-1) + α-bromoacetophenone (70-11-1) → methyl 2-phenylimidazo[1,2-a]pyridine-8-carboxylate (131862-26-5)

Guidance literature:

In butanone; at 85 ℃;

upstream raw materials:

methyl 4-n-butoxy-2-oxo-3-butenoate

guanidine hydrochloride

Downstream raw materials:

methyl 2-phenylimidazo[1,2-a]pyridine-8-carboxylate

ethyl 3-bromoimidazo[1,2-a]pyrimidine-7-carboxylate

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