4-Isoxazolecarboxylic acid, 5-(4-chlorophenyl)-3-Methyl-, ethyl

Base Information

• Chemical Name: 4-Isoxazolecarboxylic acid, 5-(4-chlorophenyl)-3-Methyl-, ethyl
• CAS No.: 97026-72-7
• Molecular Formula: C13H12ClNO3
• Molecular Weight: 265.696
• Mol file: 97026-72-7.mol

Synonyms:ethyl 5-(4-chlorophenyl)-3-methylisoxazole-4-carboxylate;4-Isoxazolecarboxylic acid, 5-(4-chlorophenyl)-3-Methyl-, ethyl;5-(4-chlorophenyl)-3-methyl-4-Isoxazolecarboxylic acid ethyl ester;5-(4-chloro-phenyl)-3-methyl-isoxazole-4-carboxylic acid ethyl ester;4-Isoxazolecarboxylic acid, 5-(4-chlorophenyl)-3-Methyl-, ethyl ester

Chemical Property of 4-Isoxazolecarboxylic acid, 5-(4-chlorophenyl)-3-Methyl-, ethyl

Chemical Property:

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Isoxazolecarboxylic acid, 5-(4-chlorophenyl)-3-Methyl-, ethyl

There total 5 articles about 4-Isoxazolecarboxylic acid, 5-(4-chlorophenyl)-3-Methyl-, ethyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-(4-chlorobenzoyl)-3-oxobutanoate (13892-47-2) → ethyl 5-(4-chlorophenyl)-3-methylisoxazole-4-carboxylate (97026-72-7)

Guidance literature:

With hydroxylamine hydrochloride; In ethanol;

DOI:10.1039/jr9630005838

Reference yield:

4-chloro-benzoyl chloride (122-01-0) → ethyl 5-(4-chlorophenyl)-3-methylisoxazole-4-carboxylate (97026-72-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine; magnesium chloride / dichloromethane / 0.5 h / 0 °C

1.2: 3 h / 20 °C

2.1: hydroxylamine hydrochloride / ethanol; water / 5 h / Reflux

With pyridine; hydroxylamine hydrochloride; magnesium chloride; In ethanol; dichloromethane; water;

DOI:10.1016/j.bmcl.2016.11.089

Reference yield:

ethyl acetoacetate (141-97-9) → ethyl 5-(4-chlorophenyl)-3-methylisoxazole-4-carboxylate (97026-72-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine; magnesium chloride / dichloromethane / 0.5 h / 0 °C

1.2: 3 h / 20 °C

2.1: hydroxylamine hydrochloride / ethanol; water / 5 h / Reflux

With pyridine; hydroxylamine hydrochloride; magnesium chloride; In ethanol; dichloromethane; water;

DOI:10.1016/j.bmcl.2016.11.089

upstream raw materials:

ethyl 2-(4-chlorobenzoyl)-3-oxobutanoate

ethyl 3-methylaminocrotonate

4-chloro-benzoyl chloride

ethyl acetoacetate

Downstream raw materials:

5-(4-chloro-phenyl)-3-methyl-isoxazole-4-carboxylic acid amide

5-(4-chloro-phenyl)-3-methyl-isoxazole-4-carboxylic acid

Refernces

• 1、 Zhang, Xuqing,Cai, Chaozhong,Winters, Michael,Wells, Michele,Wall, Mark,Lanter, James,Sui, Zhihua,Ma, Jingyuan,Novack, Aaron,Nashashibi, Imad,Wang, Yuanping,Yan, Wen,Suckow, Arthur,Hua, Hong,Bell, Austin,Haug, Peter,Clapper, Wilma,Jenkinson, Celia,Gunnet, Joseph,Leonard, James,Murray, William V.. "Design, synthesis and SAR of a novel series of heterocyclic phenylpropanoic acids as GPR120 agonists". . p. 3272 - 3278. Retrieved 2017/07/07.