13892-47-2

Upstream product

• 141-97-9 ethyl acetoacetate 
• 122-01-0 4-chloro-benzoyl chloride 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 74-11-3 para-chlorobenzoic acid 

Downstream Products

• 97026-72-7 ethyl 5-(4-chlorophenyl)-3-methylisoxazole-4-carboxylate 
• 2881-63-2 ethyl (4-chlorobenzoyl)acetate 
• 40394-89-6 p-Cl-Benzoyl-succinicacidethylester 
• 91063-36-4 5-(4-chloro-phenyl)-3-methyl-isoxazole-4-carboxylic acid amide 
• 91182-89-7 5-(4-chloro-phenyl)-3-methyl-isoxazole-4-carboxylic acid 
• 146198-54-1 ethyl N-(4-chlorobenzoyl)acetyl-N-(4-methoxy)benzylglycinate 
• 146198-61-0 1-(4-methoxy)benzyl-3-(4-chloro)benzoyl-2,4-pyrrolidindione 
• 146198-58-5 N-(4-methoxy)benzyl-N-(4-chlorobenzoyl)acetyl-glycine 

Relevant academic research and scientific papers

Design, synthesis and cytotoxic activities of scopoletin-isoxazole and scopoletin-pyrazole hybrids

12 novel scopoletin-isoxazole and scopoletin-pyrazole hybrids were designed, synthesized and their chemical structures were confirmed by HR-MS, IR,1H NMR and13C NMR spectra. The anticancer activities of the newly synthesized compounds were evaluated in vitro against three human cancer cell lines including HCT-116, Hun7 and SW620 by MTT assay. The screening results showed that six compounds (9a, 9c, 9d, 12a, 18b and 18d) exhibited potent cytotoxic activities with IC50values below 20?μM. Besides, we have further evaluated the growth inhibitory activities of six compounds against the human normal tissue cell lines HFL-1. Especially, compound 9d displayed significant anti-proliferative activity with IC50values ranging from 8.76?μM to 9.83?μM and weak cytotoxicity with IC50value of 90.9?μM on normal cells HFL-1, which suggested that isoxazole-based hybrids of scopoletin were an effective chemical modification to improve the anticancer activity of scopoletin.

Design, synthesis and SAR of a novel series of heterocyclic phenylpropanoic acids as GPR120 agonists

A novel series of 5-membered heterocycle-containing phenylpropanoic acid derivatives was discovered as potent GPR120 agonists with low clearance, high oral bioavailability and in vivo antidiabetic activity in rodents.

PIGMENT ADDITIVE, PIGMENT COMPOSITION USING THE SAME, COLORING COMPOSITION, AND COLOR FILTER

PROBLEM TO BE SOLVED: To provide: a pigment additive exhibiting extremely excellent characteristics for obtaining fine pigment; and a pigment composition which realizes a color filter made using the pigment composition or a coloring composition using the

Discovery of 3-aryl-5-acylpiperazinyl-pyrazoles as antagonists to the NK3 receptor

A series of 3-aryl-5-acylpiperazinyl-pyrazoles (e.g., 3a-b) initially identified through a high-throughput screening campaign using the aequorin Ca2+ bioluminescence assay as novel, potent small molecule antagonists of the G protein-coupled hum

SmCl3-catalyzed C-acylation of 1,3-dicarbonyl compounds and malononitrile

(Chemical Equation Presented) A recyclable, convenient, and efficient catalytic system for C-acylation of 1,3-dicarbonyl compounds and malononitrile with acid chlorides has been developed, giving moderate to excellent yields under mild conditions. This is the first catalytic example of such reactions. In addition, by applying this protocol as the key step, 3,5-disubstituted-1H- pyrazole-4-carboxylate can easily be synthesized in high yields in a one-pot procedure.

Synthesis of 3-aroyltetramic acids

Recently many dienoyl tetramic acids 5 have shown interesting antimicrobial properties and a moderate inhibition of DNA-gyrase. By structural analogy we synthesized some 3-aroyltetramic acids 6; however, they did not show any activity neither against DNA-gyrase nor against Gram positive or negative bacteria.