(3R,4S)-4-aminotetrahydro-2H-pyran-3-ol

Base Information

• Chemical Name: (3R,4S)-4-aminotetrahydro-2H-pyran-3-ol
• CAS No.: 1096770-58-9
• Molecular Formula: C5H11NO2
• Molecular Weight: 117.148
• DSSTox Substance ID: DTXSID701278114
• Mol file: 1096770-58-9.mol

Synonyms:(3R,4S)-4-aminotetrahydro-2H-pyran-3-ol;1096770-58-9;TRANS-4-AMINOTETRAHYDROPYRAN-3-OL;215940-92-4;(3R,4S)-4-AMINOOXAN-3-OL;trans-4-Amino-tetrahydro-pyran-3-ol;(3R,4S)-4-Amino-tetrahydro-pyran-3-ol;SCHEMBL1352371;PBQHDTRHGNGTLZ-WHFBIAKZSA-N;DTXSID701278114;AMY16939;MFCD22417050;AKOS025290161;DS-8018;CS-0145121

Chemical Property of (3R,4S)-4-aminotetrahydro-2H-pyran-3-ol

Chemical Property:

• PSA: 55.48000
• LogP: -0.20480
• XLogP3: -1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 117.078978594
• Heavy Atom Count: 8
• Complexity: 76.8

Purity/Quality:

97% ^*data from raw suppliers

(3R,4S)-4-Aminotetrahydro-2H-pyran-3-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1COCC(C1N)O
• Isomeric SMILES: C1COC[C@@H]([C@H]1N)O
• Uses: (3R,4S)-4-Aminotetrahydro-2H-pyran-3-ol is a useful synthetic compound

Technology Process of (3R,4S)-4-aminotetrahydro-2H-pyran-3-ol

There total 10 articles about (3R,4S)-4-aminotetrahydro-2H-pyran-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(2R)-2-acetamido-3-phenyl-propanoic acid; (3R,4S)-4-aminotetrahydropyran-3-ol → (3R,4S)-4-aminotetrahydro-2H-pyran-3-ol (1096770-58-9,1363380-59-9,1309081-53-5,1390652-01-3)

Guidance literature:

With AmberlystA₂₆(OH) resin; In methanol; dichloromethane; at 20 ℃;

Reference yield:

(3R,4S)-3-(benzyloxy)tetrahydro-2H-pyran-4-amine (1268515-66-7) → (3R,4S)-4-aminotetrahydro-2H-pyran-3-ol (1096770-58-9,1363380-59-9,1309081-53-5,1390652-01-3)

Guidance literature:

With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In methanol; at 25 ℃; for 15h; under 2068.65 Torr;

Reference yield:

Tetrahydro-4H-pyran-4-one (29943-42-8,143562-54-3) → (3R,4S)-4-aminotetrahydro-2H-pyran-3-ol (1096770-58-9,1363380-59-9,1309081-53-5,1390652-01-3)

Guidance literature:

Multi-step reaction with 7 steps

1.1: potassium hydroxide; iodine / 2.17 h / 5 °C

2.1: sodium bromate; acetic acid / ruthenium(III) trichloride hydrate / acetonitrile; water / 2 h / 30 °C

3.1: D-glucose; sodium dihydrogenphosphate; KRED-130; GDH-103; β-nicotinamide adenine dinucleotide phosphate / water / 17 h / 30 °C / pH 7.02 / Enzymatic reaction

3.2: 0.5 h

4.1: sodium t-butanolate / tetrahydrofuran / 2 h / 22 - 35 °C / Inert atmosphere

4.2: 2 h / 50 °C / Inert atmosphere

5.1: hydrogenchloride / water; tetrahydrofuran / 1.5 h

5.2: pH 7.4

6.1: hydrogenchloride; sodium formate; disodium hydrogenphosphate; L-alanin; pyridoxal 5'-phosphate; FDH; LDH; TA P₁G₅; nicotinamide adenine dinucleotide / water / 15 h / 30 °C / pH 7.25 / Enzymatic reaction

7.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / water; methanol / 15 h / 25 °C

With hydrogenchloride; sodium bromate; disodium hydrogenphosphate; sodium dihydrogenphosphate; KRED-130; L-alanin; D-glucose; FDH; GDH-103; LDH; TA P₁G₅; nicotinamide adenine dinucleotide; β-nicotinamide adenine dinucleotide phosphate; pyridoxal 5'-phosphate; hydrogen; iodine; sodium formate; acetic acid; potassium hydroxide; sodium t-butanolate; ruthenium(III) trichloride hydrate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; water; acetonitrile;

upstream raw materials:

Tetrahydro-4H-pyran-4-one

4,4-dimethoxytetrahydro-2H-pyran-3-ol

4,4-dimethoxy-5,6-dihydro-2H-pyran-3(4H)-one

(3S)-4,4-dimethoxytetrahydro-2H-pyran-3-ol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1096770-58-9 (3R,4S)-4-aMinooxan-3-ol

Send

Send

Metric Ton KG G Pound L ML

Send

Send