Methyl 2-Methyltetrahydrofuran-2-carboxylate

Base Information

• Chemical Name: Methyl 2-Methyltetrahydrofuran-2-carboxylate
• CAS No.: 1218915-91-3
• Molecular Formula: C7H12O3
• Molecular Weight: 144.16838
• Hs Code.: 2932190090
• DSSTox Substance ID: DTXSID10704885
• Mol file: 1218915-91-3.mol

Synonyms:Methyl 2-Methyltetrahydrofuran-2-carboxylate;1218915-91-3;METHYL 2-METHYLOXOLANE-2-CARBOXYLATE;MFCD18651757;TETRAHYDRO-2-METHYL-2-FURANCARBOXYLIC ACID METHYL ESTER;Methyl2-Methyltetrahydrofuran-2-carboxylate;methyl 2-methyltetrahydro-2-furancarboxylate;SCHEMBL2185550;DTXSID10704885;CWJSQEOFZMFXDO-UHFFFAOYSA-N;AKOS006366867;PB30335;AC-23580;BS-21231;SY013677;CS-0049156;FT-0710474;A891304

Chemical Property of Methyl 2-Methyltetrahydrofuran-2-carboxylate

Chemical Property:

• PSA: 35.53000
• LogP: 0.72850
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform, DCM, Ethyl Acetate, Methanol
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 144.078644241
• Heavy Atom Count: 10
• Complexity: 144

Purity/Quality:

99%, ^*data from raw suppliers

Tetrahydro-2-methyl-2-furancarboxylicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(CCCO1)C(=O)OC
• Uses: Tetrahydro-2-methyl-2-furancarboxylic Acid Methyl Ester is an intermediate in the synthesis of Mefruside (M205150), is a diuretic used for the treatment of edema and hypertension.

Technology Process of Methyl 2-Methyltetrahydrofuran-2-carboxylate

There total 1 articles about Methyl 2-Methyltetrahydrofuran-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methanol (67-56-1) + 2-methyltetrahydrofuran-2-carboxylic acid (61449-65-8) → methyl 2-methyltetrahydrofuran-2-carboxylate (1218915-91-3)

Guidance literature:

With thionyl chloride; In dichloromethane; at 0 ℃; Reflux;

Reference yield:

methyl 2-methyltetrahydrofuran-2-carboxylate (1218915-91-3) → methyl 2-(acetyloxy)-2-methyl-5-[(3-phenylpropyl)amino]pentanoate

Guidance literature:

Multi-step reaction with 2 steps

1: sodium iodide / acetonitrile / 24 h / 20 °C / Cooling with ice

2: acetonitrile / 0.5 h / Reflux

With sodium iodide; In acetonitrile;

Reference yield:

methyl 2-methyltetrahydrofuran-2-carboxylate (1218915-91-3) → methyl 2-(acetyloxy)-5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]-2-methylpentanoate

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium iodide / acetonitrile / 24 h / 20 °C / Cooling with ice

2.1: acetonitrile / 0.5 h / Reflux

3.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 1 h / 20 °C

With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium iodide; In N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

methanol

2-methyltetrahydrofuran-2-carboxylic acid

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